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Article Abstract
Background: Clinical impressions and preclinical work suggest that posttraumatic stress disorder (PTSD) might be associated with dysfunctional reward processing. To pursue this issue, we administered a validated passive-viewing monetary reward task during functional magnetic resonance imaging (fMRI) to subjects with chronic PTSD and to mentally healthy individuals.
Methods: The protocol evaluated fMRI signal changes that anticipated or accompanied monetary gains and losses under varying conditions of controlled expectation. The "expectancy phase" entailed presentation of a promising, unpromising, or intermediate Wheel of Fortune-type spinner, whereas the "outcome phase" was defined by the arrow landing on one of three sectors of that spinner, thereby determining the subjects' gain or loss for that trial.
Results: Neuroimaging data from 20 PTSD and 26 healthy subjects withstood quality control procedures and were included. In voxelwise and anatomically defined region-of-interest analyses, when gains were contrasted to losses, between-group comparison revealed smaller bilateral striatal activations in the PTSD subjects. In the PTSD group, less striatal activation to gains versus losses was associated with more self-reported motivational and social deficits.
Conclusions: The present data support the hypothesis that PTSD is associated with abnormal processing of monetary outcomes and that this alteration might be related to some aspects of emotional numbing.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9446383 | PMC |
| http://dx.doi.org/10.1016/j.biopsych.2009.06.006 | DOI Listing |
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