Memory T cells: how might they disrupt the induction of tolerance?

Transplantation

Nuffield Department of Surgery, Transplantation Research Immunology Group, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom.

Published: May 2009


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Article Abstract

Clinical and experimental evidences suggest that alloreactive memory T cells may be part of the normal T-cell repertoire and that such cells are detrimental to the survival of foreign organ allografts induced by the administration of conventional immunosuppression or experimental tolerance-inducing therapies. The potential mechanisms by which alloreactive memory T cell may form a barrier to the induction of tolerance will be discussed.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2714473PMC
http://dx.doi.org/10.1097/TP.0b013e3181a2b83bDOI Listing

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