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Since many top swimmers wearing Speedo LZR Racer swimsuits have broken world records, it is considered that the corset-like grip of suit supports the swimmers to maintain flexibility of movement and reducing water resistance. We propose an alternative mechanism to explain this phenomenon. The suits are so tight that the blood circulation of swimmers is suppressed. This effect accelerates the anaerobic glycolysis system but rather suppresses the aerobic mitochondrial respiration system. Because of the prompt production of ATP in the glycolysis system, the swimmers, especially in short distance competitions, obtain instantaneous force in white fibers of the skeletal muscles.
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http://dx.doi.org/10.2220/biomedres.30.69 | DOI Listing |
Ann Intern Med
September 2025
Department of Medicine, St Michael's Hospital, University of Toronto, Toronto, Ontario, Canada (J.G.R.).
Background: Animal studies show ovarian follicle damage and mutagenesis after ionizing radiation exposure. Computed tomography (CT) imaging is commonly done outside pregnancy, but risks to future pregnancy are unknown.
Objective: To evaluate the risk for spontaneous pregnancy loss and congenital anomalies in offspring of women exposed to CT ionizing radiation before conception.
JMIR Form Res
September 2025
Department of Health Economics, Center for Gerontology and Social Science, National Center for Geriatrics and Gerontology, Research Institute, Obu, Japan.
Background: Delayed discharge among older patients presents a major challenge for the efficiency of health service delivery. Prolonged hospitalizations limit bed turnover, increase costs, and reduce the availability of hospital resources. In Japan, older adults must undergo a formal care needs certification process to access public long-term care (LTC) services.
View Article and Find Full Text PDFPLoS One
September 2025
Department of Zoology, Baba Guru Nanak University, Nankana Sahib, Pakistan.
Secreted frizzled-related protein 4 (sFRP4) plays a fundamental role in the regulation of Wnt signalling, which is crucial for cellular proliferation and differentiation. The sFRP4 has garnered significant interest as a therapeutic target for metabolic diseases and cancer due to its mechanism of action. Although existing sFRP4 modulators show limited specificity and notable off-target effects, our study explores the potential of known bioactive compounds as more selective and less toxic alternatives.
View Article and Find Full Text PDFAm J Physiol Cell Physiol
September 2025
Humboldt-University zu Berlin, Berlin, Germany.
Skeletal muscle atrophy and weakness are major contributors to morbidity, prolonged recovery, and long-term disability across a wide range of diseases. Atrophy is caused by breakdown of sarcomeric proteins resulting in loss of muscle mass and strength. Molecular mechanism underlying the onset of muscle atrophy and its progression have been analysed in patients, mice, and cell culture but the complementarity of these model systems remains to be explored.
View Article and Find Full Text PDFArch Pharm Res
September 2025
College of Pharmacy, Hanyang University, Ansan, 15588, Republic of Korea.
c-Jun N-terminal kinases (JNKs), a subfamily of mitogen-activated protein kinases (MAPKs), are key mediators of cellular responses to environmental stress, inflammation, and apoptotic signals. The three isoforms-JNK1, JNK2, and JNK3 exhibit both overlapping and isoform-specific functions. While JNK1 and JNK2 are broadly expressed across tissues and regulate immune signaling, cell proliferation, and apoptosis, JNK3 expression is largely restricted to the brain, heart, and testis, where it plays a crucial role in neuronal function and survival.
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