Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Pigment-dispersing factor (PDF) is a neuropeptide that is synthesized specifically and constantly in the circadian clock cells of many insects. The functions of PDF have not been fully determined, but it might serve as the output and coupling signal of circadian locomotor rhythms. In this experiment, we explore the functions of PDF in the German cockroach with RNA interference technique. Since the 2nd day after pdf double-strand RNA (dsRNA) injection, the amount of pdf mRNA decreased significantly, and this knockdown effect could persist at least 56 days. With immunostaining technique, the clock cells of pdf dsRNA-injected cockroaches could not be stained by anti-PDF antibody. In the behavioral study, pdf dsRNA injection caused rhythmic males to become arrhythmic in light-dark cycles or in constant darkness. In addition, due to the nocturnal nature of the German cockroaches, the locomotor activity increased after lights-off or entering subjective night. However, this activity peak gradually disappeared after pdf dsRNA injection. Based on these 2 lines of evidences, PDF serves as an output regulator of locomotor circadian rhythm in the German cockroach.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1177/0748730408327909 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
On the species status of and (Blattodea, Blattellidae), and other morphologically similar species.
Zookeys
August 2025
College of Plant Protection, Southwest University, Beibei, Chongqing 400715, China Southwest University Beibei China.
(Linnaeus, 1767), a member of the Blattellidae family within the order Blattodea, is a significant global sanitary pest. Several species within the genus Caudell, 1903 and its closely related genera ( Bey-Bienko, 1950; Hebard, 1916; and Hebard, 1929) exhibit external morphological traits similar to those of . By integrating morphological identification and molecular analyses, one new species was identified: Cai, Yao & Che, Additionally, Mizukubo, 1981 was downgraded to a subspecies of .
View Article and Find Full Text PDFEffect of capsaicin on voltage-gated sodium channels with mutation from German cockroaches ().
J Pestic Sci
August 2025
The United Graduate School of Agriculture, Ehime University.
Capsaicin inhibits the current flow in the voltage-gated sodium channels (VGSCs) of mammals and insects. The aim of the present study was to elucidate capsaicin toxicity in pyrethroid-susceptible and knockdown resistant (; with reduced pyrethroid sensitivity) strains of the German cockroach () and its effects on VGSCs carrying the mutation. Injection tests revealed that adult cockroaches from susceptible and strains exhibited sluggish movement and paralysis upon abdominal capsaicin administration, consistent with its inhibitory effect on VGSC currents.
View Article and Find Full Text PDFToxicant translocation and colony impact in the Pharaoh ant (Hymenoptera: Formicidae) after consumption of gel bait-killed German cockroach (Blattodea: Ectobiidae) cadavers.
J Econ Entomol
August 2025
Department of Entomology, University of California, Riverside, CA, USA.
This study investigated the translocation of cockroach bait toxicants to the Pharaoh ant, Monomorium pharaonis (L.), through feeding on cadavers of German cockroaches, Blattella germanica (L.), which were killed by commercial gel baits.
View Article and Find Full Text PDFInteraction between expression of CD23 on B-lymphocytes and level of specific IgE against molecular components of NPC2 family, lipocalins, uteroglobins, and molecular components of molds and yeast.
J Immunotoxicol
December 2025
Department of Clinical Immunology and Allergy, Faculty Hospital, Medical Faculty of Charles University, Hradec Králové, Czech Republic.
The aim of this study was to assess the relationship between the expression of the CD23 molecule on B-cells and the levels of specific IgE against allergens and molecular components of storage mites (Gly d 2, Lep d 2), dog (Can f 1, Can f 2), cat (Fel d 1), shrimp (Pen m 2), molds (Asp f 6, Mala s 11, Alt a 6, Alt a 1, Mala s 6, Cla h), and German cockroach (Bla g 9) in atopic dermatitis (AD) patients (with and without dupilumab therapy). Here, 46 patients with AD were included (26 without dupilumab treatment, 20 with dupilumab treatment). Serum levels of specific IgE were measured using the component-resolved diagnostic microarray ALEX2 Allergy Xplorer, and the expression of the CD23 molecule on B-cells was evaluated using flow cytometry.
View Article and Find Full Text PDFHigh-content phenotypic screening reveals natural product bioactives that disrupt mosquito activity, development and serotonergic signaling.
Pestic Biochem Physiol
September 2025
Department of Entomology, Purdue University, West Lafayette, IN 47907-2089, USA. Electronic address:
Mosquitoes are one of the most prolific disease vectors in nature, transmitting many infectious diseases, such as dengue, malaria, and yellow fever. Vector eradication campaigns are failing due to the increasing insecticide resistance shown by mosquito populations, causing efficacy loss of currently available chemistries due to their limited mode of action. Natural products (NPs) are chemistries with diverse chemical structures and potential unique modes of action for mosquito control.
View Article and Find Full Text PDF