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Sci Transl Med
September 2025
Burn Injury Research Unit, School of Biomedical Sciences, University of Western Australia, Perth, Western Australia 6009, Australia.
Skin scars remain a substantial clinical challenge because of their impact on appearance and psychological well-being. Lysyl oxidases catalyze collagen cross-linking, a key factor in scar development. Here, we report a randomized, double-blind, placebo-controlled phase 1 study to assess the safety and tolerability of PXS-6302, a topical pan-lysyl oxidase inhibitor, in treating mature scars (ACTRN12621001545853).
View Article and Find Full Text PDFInt J Pharm
September 2025
Programa de Pós-Graduação em Ciências Farmacêuticas, Faculdade de Farmácia Universidade Federal do Rio Grande do Sul, Avenida Ipiranga, 2752, Porto Alegre, Rio Grande do Sul 90610-000, Brazil; Laboratório de Nanocarreadores e Impressão 3D em Tecnologia Farmacêutica (Nano3D), Faculdade de Fa
The implementation of 3D printing technologies in clinical settings depends on formulations that are not only printable and compliant with quality standards but also physicochemical stable and reliable under real-use conditions. This study evaluated the in-use and long-term physicochemical and rheological stability of two hydrogel inks developed for semisolid extrusion (SSE) 3D printing: one containing pimobendan (PBD) and the other a placebo. PBD is a poorly water-soluble drug used to treat canine heart failure, whose formulation challenges highlight the potential of personalised drug delivery.
View Article and Find Full Text PDFInt J Nanomedicine
September 2025
Guangxi Key Laboratory of Special Biomedicine; School of Medicine, Guangxi University, Nanning, Guangxi Zhuang Autonomous Region, 530004, People's Republic of China.
Cancer remains one of the leading causes of mortality worldwide. Although conventional treatment strategies such as chemotherapy, radiotherapy, and surgery have demonstrated therapeutic potential, their clinical effectiveness is often limited by poor targeting specificity, systemic toxicity, and inadequate treatment monitoring. Magnetic resonance imaging (MRI) has emerged as a powerful diagnostic modality owing to its non-invasive nature, high spatial resolution, deep tissue penetration, and real-time imaging capabilities, making it particularly suitable for guiding and evaluating cancer therapies.
View Article and Find Full Text PDFFront Oncol
August 2025
Nursing of Colloge, Jiangxi University of Chinese Medicine, Nanchang, Jiangxi, China.
Objective: This study aims to comprehensively evaluate the efficacy of different non-pharmacological interventions in treating constipation symptoms in lung cancer patients through a network meta-analysis, providing evidence-based support for personalized treatment decisions in clinical practice.
Methods: We retrieved randomized controlled trials (RCTs) from well-known databases and compared the efficacy of non-pharmacological interventions with traditional treatments or placebos in improving constipation symptoms in lung cancer patients. The search was conducted through January 2025.
BMC Complement Med Ther
September 2025
Acupuncture and Tuina School, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Background: The clinical effects of acupuncture are often underestimated due to the placebo effect of sham acupuncture. While multiple sham acupuncture methods have been used in clinical practice, it is challenging to select the appropriate sham acupuncture technique due to the lack of head-to-head trials.
Purpose: The purpose of this study was to compare the differential placebo effects of diverse sham acupuncture interventions, providing evidence-based guidance for selecting optimal placebo controls in clinical practice.