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Objective: The purpose of this study was to examine the prevalence of pulp calcifications in patients with Marfan syndrome.
Study Design: The prevalence of pulp stones and pulp obliteration was evaluated on bitewing radiographs in 21 subjects with Marfan syndrome and in 100 healthy controls.
Results: Subjects with Marfan syndrome older than 30 years of age showed a significantly higher prevalence of pulp stones (P = .027) or pulp obliteration (P < .001). Pulp stones were present in 20.7% and pulp obliteration was found in 7.9% of the examined teeth in this group. Subjects with Marfan syndrome also revealed a significant correlation between age and number of teeth with pulp stones or pulp obliteration.
Conclusion: The results of the present study indicate that pulp calcifications are frequent findings in subjects with Marfan syndrome. This should be taken into consideration in endodontic or orthodontic treatment.
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http://dx.doi.org/10.1016/j.tripleo.2008.06.029 | DOI Listing |
Eur Heart J Case Rep
September 2025
Department of Radiology, The First Affiliated Hospital of Bengbu Medical University, No. 287 Changhuai Road, Bengbu, Anhui Province 233004, China.
Background: Fulminant myocarditis (FM) is a rare but serious inflammatory disease of the heart that should be considered for extracorporeal membrane oxygenation (ECMO) supportive therapy when it occurs. The diagnosis of FM is made more difficult in the context of Marfan's syndrome combined with aortic root dilation. We report a case of a patient on ECMO support and with comorbid Marfan's syndrome who was finally diagnosed with FM after computed tomography angiography (CTA) differentiated between FM, coronary artery disease, and aortic root dilation.
View Article and Find Full Text PDFDrug Des Devel Ther
September 2025
Key Laboratory for Genetic Disease in Sichuan Province, Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, People's Republic of China.
Marfan syndrome (MFS) is a hereditary connective tissue disorder that is primarily caused by mutations in the fibrillin-1 () gene. This disease predominantly affects the eyes, bones, and cardiovascular system, with cardiovascular complications posing the most significant threat to life. Currently, conventional treatments, which are based on pharmacological management and surgical interventions, aim to slow disease progression and manage life-threatening cardiovascular complications.
View Article and Find Full Text PDFMultimed Man Cardiothorac Surg
September 2025
Department of Cardiovascular Surgery, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina.
The David procedure has been extensively studied as an elective treatment when valve anatomy and function permit valve-sparing aortic root replacement. This approach is particularly beneficial in young patients who also require mitral valve repair and treatment for mitral annular disjunction. This video tutorial provides a step-by-step guide to the David V procedure in a female patient with Marfan syndrome, presenting with an aortic root aneurysm, severe mitral regurgitation and mitral annular disjunction.
View Article and Find Full Text PDFMicroPubl Biol
August 2025
Biomedical Sciences, Southern Illinois University Carbondale, Carbondale, Illinois, United States.
Marfan Syndrome (MFS) is an autosomal dominant genetic disorder that affects connective tissue throughout the body due to mutations in the fibrillin-1 ( gene. There is a gap in our understanding of the impact of monogenic connective tissue aberrations on the brain. This study aimed to determine the impact of MFS on neurodegeneration in the cortical brain tissue of mice.
View Article and Find Full Text PDFDisabil Rehabil
September 2025
TRS National Resource Centre for Rare Disorders, Department of Innovation and Research, Sunnaas Rehabilitation Hospital, Nesodden, Norway.
Purpose: Stickler syndrome is a rare, hereditary connective tissue disorder characterized by visual, auditory, and musculoskeletal complications. Research on quality of life remains limited. This study aimed to: (i) explore existing literature on psychosocial aspects, pain, fatigue, and quality of life in individuals with Stickler syndrome, (ii) describe the impact of health complaints on daily living, contacts with healthcare- and social service systems and quality of life in a cohort of adults with Stickler syndrome.
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