Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
In contrast to transport across basolateral membranes, the mechanism governing transport of organic anions across the luminal membranes of proximal tubules has remained unclear. We recently found Tetracycline transporter-like protein (TETRAN), a human ortholog of yeast Tpo1p that can transport anionic Non-steroidal anti-inflammatory drugs (NSAIDs). In this study, we examine the expression and function of TETRAN. TETRAN mRNA is expressed in various human tissues, including kidney. When overexpressed in cultured cells, TETRAN was predominantly localized on cytoplasmic membranes. Immunohistochemical analysis of human and mouse kidney tissue showed that TETRAN was expressed at the luminal membranes of proximal tubules. Overexpression of TETRAN in cultured cells facilitated the uptake of organic anions such as indomethacin (a NSAID) and fluorescein. The results suggest that TETRAN is a novel human organic anion transporter, and that it serves as a transporter for some NSAIDs and various other organic anions at the final excretion step.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.bbrc.2008.07.034 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Enhanced corrosion inhibition of S235JR steel using anionic clay-phenolic extract hybrids: findings of synergistic action.
Int J Environ Health Res
September 2025
Laboratory of Extremophile Plants, Center of Biotechnology of Borj-Cedria, BP 901, HammamLif, Tunisia.
Corrosion of mild steel in marine environments poses a major challenge for industrial sustainability. This study aims to develop an eco-friendly corrosion protection approach by combining phenolic extracts (PE) from extremophile plants with Zn₂-Al-layered double hydroxides (LDH) to form hybrid inhibitors for S235JR steel in artificial seawater (3.5% NaCl).
View Article and Find Full Text PDFUnveiling the synergistic mechanisms of multi-ionic removal in microbial desalination cells: Ion transfer, electrochemical behavior and microbial response.
Bioresour Technol
September 2025
Institute of Urban Agriculture, Chinese Academy of Agricultural Sciences, Chengdu 610213, China. Electronic address:
Microbial desalination cells (MDCs) have traditionally employed simplified NaCl solutions as feedwater for synchronous desalination and bioenergy recovery. Nevertheless, the specific mechanisms by which MDCs remove complex multi-ions from saline wastewater remain obscure. This study thoroughly investigated ion migration, bioelectrochemical dynamics, and microbial ecological responses across three distinct configurations: monovalent ions - PMDC, divalent cations - CMDC and anions - AMDC.
View Article and Find Full Text PDFPicric Acid Removal from Water Using an Anion-Coordination-Based Supramolecular Organic Framework.
J Am Chem Soc
September 2025
Key Laboratory of Catalysis and Energy Materials Chemistry of Ministry of Education & Hubei Key Laboratory of Catalysis and Materials Science, South-Central Minzu University, Wuhan 430074, China.
In contrast to metal ions that have been routinely used to construct metal-organic frameworks (MOFs), anions have rarely been used as essential coordination centers in supramolecular organic frameworks (SOFs). In this work, we present a SOF, , based on the coordination of chloride anions and a flexible oligopyrrole. Owing to the multiple interactions between individual oligopyrrole molecules and an A-B-C-style stacking of the 2D honeycomb layers, crystalline exhibits reasonable thermal stability and retains its structure upon desolvation.
View Article and Find Full Text PDFHydroperoxide-Induced Nitrile Migration in Azolo[1,5-]pyrimidine-6-carbonitriles: An Original Approach toward Functionalized Azolopyrimidines.
J Org Chem
September 2025
Ural Federal University Named After the First President of Russia B. N. Yeltsin, Mira Str. 19, Ekaterinburg 620062, Russia.
Azolo[1,5-]pyrimidines (APs) are widely recognized as challenging scaffolds for diverse applications in both medicinal chemistry and materials science. Owing to their high potential, active research is focused on developing new derivatives through the derivatization and functionalization of their molecular structure. Herein, we report an unusual transformation in the AP series initiated by a hydroperoxide anion.
View Article and Find Full Text PDFA solid-state battery capable of 180 C superfast charging and 100% energy retention at -30 °C.
Proc Natl Acad Sci U S A
September 2025
Department of Materials Science and Engineering, City University of Hong Kong, Kowloon, Hong Kong 999077, China.
Solid-state electrolytes (SSEs) are being extensively researched as replacements for liquid electrolytes in future batteries. Despite significant advancements, there are still challenges in using SSEs, particularly in extreme conditions. This study presents a hydrated metal-organic ionic cocrystal (HMIC) solid-state ion conductor with a solvent-assisted ion transport mechanism suitable for extreme operating conditions.
View Article and Find Full Text PDF