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Objective: To evaluate the resistance to fracture of endodontically treated teeth restored with combined composite-amalgam restorations in comparison to all-amalgam restorations.
Method And Materials: Forty-eight human premolar teeth were equally divided into 4 groups. Mesio-occlusodistal (MOD) cavities were prepared in 3 groups, and in the fourth group, a modified MOD preparation was designed with an additional buccolingual groove. All teeth were endodontically treated and restored using 1 of several restorative modalities: all amalgam (AM), all amalgam plus dentin adhesive (ADA), amalgam plus dentin adhesive plus composite resin (ADAC), and amalgam plus dentin adhesive plus composite resin with a modified preparation design (ADACM). Specimens were tested in a universal testing machine (Instron). The load (in kilonewtons) at fracture was recorded and statistically analyzed using a Bonferroni one-way statistical analysis (significance: P
Results: The teeth restored with a combined composite-amalgam restoration were significantly more resistant to fracture ( P
Conclusions: Restoration of endodontically treated teeth with combined composite-amalgam materials increased tooth resistance to fracture up to 51% when compared to teeth restored with amalgam alone.
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Eur J Dent
September 2025
Doctoral Program, Faculty of Dentistry, Universitas Indonesia, Jakarta, Indonesia.
Although platelet-rich plasma (PRP) has demonstrated considerable regenerative potential in regenerative endodontic treatment, its clinical efficacy may be limited by the rapid degradation of its bioactive components, leading to inconsistent outcomes. To overcome this challenge, the present study explores the use of nano-sized exosomes derived from PRP-a novel designated as PRP exosomes (PRP-Exo)-as a more stable and targeted biomolecular delivery system to promote odontogenic differentiation within the dentin-pulp complex. The primary objective is to investigate the expression of key odontogenic markers, transforming growth factor-β1 (TGF-β1) and Dentin Sialophosphoprotein (DSPP), in human dental pulp stem cells (hDPSCs) following PRP-Exo treatment.
View Article and Find Full Text PDFCureus
August 2025
Department of Orthodontics, Kothiwal Dental College and Research Centre, Moradabad, IND.
Introduction: This study aimed to evaluate and compare the inflammatory responses of two cordless gingival retraction systems by assessing the levels of interleukin-1 beta (IL-1β) and tumor necrosis factor-alpha (TNF-α) in gingival crevicular fluid (GCF). The objectives were to measure IL-1β and TNF-α levels before and after retraction using kaolin-based and polyvinyl acetate-based cordless gingival retraction materials at baseline, 1 h, and 24 h, and to compare the inflammatory profiles of these materials.
Materials And Methods: This in-vivo comparative study used a split-mouth design, with each of the 10 enrolled patients serving as their own control by receiving both kaolin-based paste (Traxodent®, Premier Dental Products, Plymouth Meeting, PA, USA) and polyvinyl acetate-based strip (Merocel®, Medtronic, Minneapolis, MN, USA) on different endodontically treated teeth requiring full-coverage crowns, thereby minimizing interindividual variability.
J Dent
September 2025
State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, National Clinical Research Center for Oral Diseases, Sichuan University, Chengdu 610041, China; Department of Operative Dentistry and Endodontics, West China School of Stomatology, Sichuan University, Chengdu 610041, China. E
Objectives: The aim of this study is to explore the specific application scenarios of quantitative light-induced fluorescence (QLF) in the detection and treatment of early caries, so as to provide more evidence for the clinical application of QLF.
Methods: (1) The accuracy of QLF in detecting the lesion depth of early caries was evaluated by combining transverse microradiography (TMR) and spectrophotometer analysis (n=6). (2) Resin infiltration therapy was used as a representative method for the treatment of early caries to evaluate the ability of QLF in assessing the therapeutic effect on early caries (n=6).
Immun Inflamm Dis
September 2025
Department of Conservative Dentistry and Endodontics, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, Tamil Nadu, India.
Objectives: The current systematic review and meta-analysis aims to assess the safety and immunogenicity of the anticaries vaccines currently available.
Materials And Methods: Electronic searches of PubMed, Scopus, Web of Science and Science Direct were performed. Studies assessing the safety and effectiveness of the anticaries vaccination, including the dose, plasmids, serum IgG and IgA levels after immunization, were included.
F1000Res
September 2025
Associate professor, Department of Conservative Dentistry and Endodontics, Sharad Pawar Dental College, Datta Meghe Institute of Higher Education and Research, Sawangi, wardha, Maharashtra, 442001, India.
One of the common forms of dental injury is anterior crown fractures, which mainly affect teenagers and young adults. Fractures of the coronal portion of the permanent incisors characterize 18-22% of total traumatic injuries to dental hard tissues, of which 96% of them comprise the maxillary incisors. An uncomplicated fracture of the crown is one of the most common types of dental traumatic injury.
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