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Objective: To determine the contents of saikosaponin a, d and saikosaponins in Radix Bupleuri from different and assess their quality.
Method: Saikosaponin a and d were used as the chemical reference substance to establish RP-HPLC and visible-spectrophotometry methods for determination of contents of saikosaponin a, d and saikosaponins.
Result: The quality of B. chinense was better than that of B. scozonerifolium and B smishii; The contents of a, saikosaponin d and total saikosaponin in B. chinense were 0.100%-0.330%, 0.200%-0.400% and 1.00%-2.00% , respectively.
Conclusion: It is to suggest that the minimal contents requirements of saikosaponin a, d and saikosaponins in B. chinense should be set at 0. 100% , 0.200% and 1.00% , respectively; the best suitable planting areas are Taigu in the middle of Shanxi province, Ruicheng, Pinglu and Wanrong in the south of Shanxi province, and Longxi, Lixian in Gansu province.
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Biology (Basel)
July 2025
School of Pharmacy, Heilongjiang University of Traditional Chinese Medicine, Harbin 150040, China.
Willd. is a perennial herbaceous plant of the genus in the Apiaceae family. Also known as red , it is mainly distributed in Northeast China, North China and other regions and is a commonly used medicinal plant.
View Article and Find Full Text PDFInhal Toxicol
April 2025
Department of Endocrinology, The First Affiliated Hospital of Bengbu Medical University, Bengbu, China.
Background: Saikosaponin D (SSD), a triterpenoid saponin extracted from , has many pharmacological properties. The goal of our study is to assess the roles and mechanisms of SSD in septic acute lung injury (ALI).
Methods: ALI in mice was induced by cecal ligation and puncture (CLP).
Planta
June 2025
School of Pharmacy, Heilongjiang University of Chinese Medicine, Harbin, 150040, Heilongjiang, China.
Suitable environments (low light, drought, adequate nutrients, moderate salinity, low temperature) and microorganisms (endophytic fungi, AMF, Trichoderma) promote saikosaponins accumulation by regulating key enzymes and transcription factors in biosynthetic pathways. Saikosaponins (SSs) are the principal bioactive constituents and crucial quality control markers in the genus Bupleurum. They possess diverse pharmacological activities, such as sedation, antipyretic, anticonvulsant, anti-inflammation, antitumor, antiviral, and hepatoprotection.
View Article and Find Full Text PDFBiology (Basel)
April 2025
School of Pharmacy, Heilongjiang University of Traditional Chinese Medicine, Harbin 150040, China.
Willd. is a commonly used bulk Chinese herbal remedy. Due to the large-scale mining of wild Willd.
View Article and Find Full Text PDFFront Pharmacol
April 2025
School of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing, China.
Introduction: Wuling capsule is a Chinese patent medicine mainly used for the treatment of chronic liver disease in clinical practice. Our previous work has revealed that Wuling capsule could inhibit liver fibrosis by regulating macrophage polarization, and firstly demonstrated its anti-gout effects on monosodium urate (MSU)- induced acute gouty arthritis (AGA) in rats. High uric acid (UA) levels are known to be the primary cause of gout.
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