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Objective: The objective of the study was to describe a five-step protocol for withholding and withdrawing of life support (WH/WDLS) in an emergency department (ED) for terminally ill patients.
Design And Setting: An observational study was conducted in ED of a general hospital.
Patients: A total of 98 patients were admitted over a 1-year period.
Interventions: The healthcare team chose a pattern of treatment limitation on the basis of a five-step protocol for every patient, which comprised five groups: group 1: there was no limitation of care, group 2: do not resuscitate order was followed, group 3: administration of therapies without treating an acute organ failure, group 4: active withdrawal of all therapies except mechanical ventilation and group 5: active withdrawal of mechanical ventilation. All the patients received comfort care. The opinions of the patients and their families were collected.
Measurements And Results: Ninety-eight patients were included in the study (1.5% of admissions). Mean age was 82+/-13 years. An acute organ failure was observed at admission in 80 patients. Severe chronic disease was noted in 93 patients. Among the 98 patients, there were 14 patients in group 2, 65 in group 3, six in group 4 and 13 in group 5. The time interval between admission and WH/WDLS decision was 117+/-77 min and ED stay was 239+/-136 min. The outcome was death in ED (n=21), admission to a medical ward (n=71) or an intensive care unit (n=six). On day 30, 16 patients were still alive.
Conclusion: This five-step protocol could improve collaboration in the WH/WDLS decision-making process, while facilitating dialogue and transmission of information between staff and families.
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http://dx.doi.org/10.1097/MEJ.0b013e3282f01147 | DOI Listing |
Molecules
August 2025
Medicinal Biotechnology Department, Sirius University of Science and Technology, Olimpiyskiy Ave. 1, 354340 Sirius, Krasnodar Region, Russia.
Several approaches to the synthesis of risdiplam, a pharmacologically relevant pyridopyrimidinone derivative, have been recently reported. However, most of these routes rely exclusively on palladium-catalyzed, cross-coupling reactions and involve low-yielding intermediates, which limit their scalability and complicate impurity control. In this work, we present a five-step, straightforward route to risdiplam, utilizing ethyl 2,8-dimethylimidazo[1,2-]pyridazine-3-carboxylate-an accessible and cost-effective building block previously developed by our research group-as a starting material.
View Article and Find Full Text PDFBMJ Open
August 2025
Factor Inwentash Faculty of Social Work, University of Toronto, Toronto, Ontario, Canada.
Introduction: Sexual violence remains a critical and under-reported issue in postsecondary institutions, impacting student health, well-being and academic outcomes. In Canada, over 90% of incidents are not disclosed to institutions; similar patterns are observed in the USA. Despite growing awareness of the issue, no comprehensive review has synthesised how Canadian evidence understands the disclosure of sexual violence in postsecondary settings.
View Article and Find Full Text PDFBackground: Across many countries, the number of older people from ethnic minority communities is growing due to ageing populations and migration trends. In England and Wales, the population of older people from ethnic minority communities, particularly those aged 60 and above, is also increasing. This demographic change, often accompanied by the prevalence of polypharmacy in these communities, presents unique challenges in the context of medicine optimisation.
View Article and Find Full Text PDFJMIR Res Protoc
August 2025
Michigan Innovations in Addiction Care through Research & Education Program, Addiction Center, Department of Psychiatry, University of Michigan-Ann Arbor, Ann Arbor, MI, United States.
Background: Remote recruitment for human participant research is increasingly popular due to its speed, cost-effectiveness, and accessibility for participants. However, in some cases, it can be particularly difficult to authenticate participants recruited remotely, which, unless adequately addressed, may pose a threat to data integrity and validity.
Objective: This protocol aims to outline authenticity concerns encountered via remote recruitment for a longitudinal cohort study of adults reporting polysubstance use.
BMJ Open
July 2025
Mental Health Nursing, Independent Scholar, Dundee, UK.
Introduction: Forensic mental health nursing (FMHN) is a subspeciality of psychiatric nursing. An area of mental health nursing care that is situated at the intersection of health, social and criminal justice systems. Over the past two decades, FMHN has evolved beyond custodial and containment practice.
View Article and Find Full Text PDF