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Article Abstract
Unlabelled: Sequence-directed mapping of nucleosome positions is of major biological interest. Here, we present a web-interface for estimation of the affinity of the histone core to DNA and prediction of nucleosome arrangement on a given sequence. Our approach is based on assessment of the energy cost of imposing the deformations required to wrap DNA around the histone surface. The interface allows the user to specify a number of options such as selecting from several structural templates for threading calculations and adding random sequences to the analysis.
Availability: The nuScore interface is freely available for use at http://compbio.med.harvard.edu/nuScore.
Contact: peter_park@harvard.edu; tolstorukov@gmail.com
Supplementary Information: The site contains user manual, description of the methodology and examples.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3807124 | PMC |
| http://dx.doi.org/10.1093/bioinformatics/btn212 | DOI Listing |
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nuScore: a web-interface for nucleosome positioning predictions.
Bioinformatics
June 2008
Harvard-Partners Center for Genetics and Genomics, Brigham and Women's Hospital, Boston, MA 02115, USA.
Unlabelled: Sequence-directed mapping of nucleosome positions is of major biological interest. Here, we present a web-interface for estimation of the affinity of the histone core to DNA and prediction of nucleosome arrangement on a given sequence. Our approach is based on assessment of the energy cost of imposing the deformations required to wrap DNA around the histone surface.
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