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Polydextrose is a randomly bonded polysaccharide produced by the bulk melt polycondensation of glucose and sorbitol in vacuo. It has been used as a bulking and texturizing agent and soluble fiber ingredient in many food products worldwide for over two decades. Because of its atypical linkages between glucose moieties, polydextrose resists digestion by mammalian gastrointestinal enzymes. It is minimally absorbed in the small intestine and partially fermented in the large intestine producing volatile fatty acids, with approximately 50% of the ingested dose being excreted undigested. In this it is similar to many other poorly digested soluble fiber ingredients. Numerous energy balance and isotope-label disposition studies have been conducted in animals and man to investigate the caloric availability of polydextrose. The weight of available experimental evidence in the 14 studies described herein shows that polydextrose has a caloric value of approximately 1 kcal/g.
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http://dx.doi.org/10.1301/nr.2007.dec.544-549 | DOI Listing |
Front Neurosci
August 2025
Beijing Life Science Academy, Beijing, China.
Hypocretin, also known as orexin, is a hypothalamic neuropeptide that regulates essential physiological processes including arousal, energy metabolism, feeding behavior, and emotional states. Through widespread projections and two G-protein-coupled receptors-HCRT-1R and HCRT-2R-the hypocretin system exerts diverse modulatory effects across the central nervous system. The role of hypocretin in maintaining wakefulness is well established, particularly in narcolepsy type 1 (NT1), where loss of hypocretin neurons leads to excessive daytime sleepiness and cataplexy.
View Article and Find Full Text PDFFood Res Int
November 2025
College of Agriculture, Henan University, Kaifeng 475004, China; School of Food and Pharmacy, Xuchang University, Xuchang 461000, China. Electronic address:
High- and low-protein diets have long been debated for their effects on body fat accumulation, which may stem from neglecting interactions with other macronutrients. This study investigates how the dietary carbohydrate-to-protein caloric ratio (CPCR) affects hepatic fat deposition via the IGF-1/PI3K/Akt signaling pathway. Within an isocaloric dietary framework, we evaluated the effects of varying CPCR (dietary fat held constant at 10 %) on hepatic fat accumulation in Sprague-Dawley rats over 8 weeks.
View Article and Find Full Text PDFCureus
August 2025
Family Medicine, West Virginia University, Morgantown, USA.
Introduction: Bodybuilding is a sport of self-discipline and pushing the human body to the extreme limits, often accomplished with drastic training methods and supplement usage, which have the potential to be associated with severe health consequences. Various aspects of bodybuilding competition preparation, such as nutrition, exercise, and drug/supplement utilization, contribute to changes in female athletes' menstrual health.
Methods: An anonymous survey was conducted in women of reproductive age who were 18 and older assessing various techniques used during competition preparation and their menstrual cycles.
Biomed Pharmacother
August 2025
Rutgers University, Department of Biology and Center for Computational and Integrative Biology, Camden, NJ 08103, USA. Electronic address:
Mitochondria play a crucial role in multiple cellular processes beyond the regulation of bioenergetics. These processes range from apoptosis to intracellular signaling. Accordingly, mitochondrial dysfunction has been broadly described in the etiopathology of multiple human diseases, including cancer, diabetes, and all the main neurodegenerative disorders.
View Article and Find Full Text PDFFoods
August 2025
Department of Biochemistry and Food Chemistry, University of Life Sciences in Lublin, St. Akademicka 13, 20-950 Lublin, Poland.
Monk fruit extract (, MFE) is a natural, non-caloric sweetener known for its intense sweetness, antioxidant properties, and potential metabolic health benefits. While certain aqueous monk fruit decoctions are recognised as non-novel foods in the UK and Ireland due to significant pre-1997 consumption, the European Union (EU) has adopted a more cautious approach under the Novel Food Regulation (EU) 2015/2283. As of October 2024, only one specific aqueous extract of monk fruit has been authorised in the EU under Regulation (EU) 2024/2345, permitting its use in several food categories.
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