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This article proposes 2 new approaches to test a nonzero population correlation (rho): the hypothesis-imposed univariate sampling bootstrap (HI) and the observed-imposed univariate sampling bootstrap (OI). The authors simulated correlated populations with various combinations of normal and skewed variates. With alpha set=.05, N> or =10, and rho< or =0.4, empirical Type I error rates of the parametric r and the conventional bivariate sampling bootstrap reached .168 and .081, respectively, whereas the largest error rates of the HI and the OI were .079 and .062. On the basis of these results, the authors suggest that the OI is preferable in alpha control to parametric approaches if the researcher believes the population is nonnormal and wishes to test for nonzero rhos of moderate size.
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http://dx.doi.org/10.1037/1082-989X.12.4.414 | DOI Listing |
Health Serv Res
September 2025
Division of Clinical Informatics and Digital Transformation, Director, Center for Clinical Informatics and Improvement Research, University of California - San Francisco, San Francisco, CA, San Francisco, California, USA.
Objective: To analyze national rates of team-based ordering and evaluate changes in key outcomes following adoption.
Study Setting And Design: We conducted an observational pre-post intervention-comparison study of 249,463 ambulatory physicians across 401 organizations using the Epic EHR. Our intervention was the adoption of team-based ordering, measured as the proportion of orders involving team support.
Here, we present a novel approach to estimate the degree to which the phenotypic effect of a DNA locus is attributable to four components: alleles in the child (direct genetic effects), alleles in the mother and the father (indirect genetic effects), or is dependent upon the parent from which it is inherited (parent-of-origin, PofO effects). Applying our model, JODIE, to 30,000 child-mother-father trios with phased DNA information from the Estonian Biobank (EstBB) and the Norwegian Mother, Father, Child Cohort (MoBa), we jointly estimate the phenotypic variance attributable to these four effects unbiased of assortative mating (AM) for height, body mass index (BMI) and childhood educational test score (EA). For all three traits, direct effects make the largest contribution to the genetic effect variance.
View Article and Find Full Text PDFPercept Mot Skills
September 2025
Department of Clinical Sciences, Otorhinolaryngology Head and Neck Surgery, Skåne University Hospital, Lund University, Lund, Sweden.
When patients experience peripheral vestibular or certain central disorders causing dizziness or vertigo, this is sometimes associated with experiencing also disrupted spatial orientation, which may be accentuated by exposure to a distorted visual environment. This study explores the impact of sensorimotor factors and sex on spatial orientation in sitting and standing positions. In the Rod-and-Frame test, the participant views a rod - with and without a surrounding tilted frame - and is assigned to align the rod vertically or horizontally.
View Article and Find Full Text PDFCancer Med
September 2025
Dow Division of Health Services Research, Department of Urology, University of Michigan, Ann Arbor, Michigan, USA.
Introduction: Men with newly diagnosed prostate cancer often appropriately elect for either immediate treatment or conservative management. The out-of-pocket costs they face vary by management strategy, with immediate treatment often superseding those of conservative management, potentially influencing patient decisions. We estimated the anticipated out-of-pocket costs that commercially insured men with newly diagnosed prostate cancer face and measured their association with immediate treatment.
View Article and Find Full Text PDFJ Med Internet Res
August 2025
Behavioral Science Division, National Center for Posttraumatic Stress Disorder, VA Boston Healthcare System, 150 S Huntington Ave, 13B, Boston, MA, 02130, United States, 1 6172329500.
Background: Electronic health record (EHR) data are increasingly used in predictive models of posttraumatic stress disorder (PTSD), but it is unknown how multivariable prediction of an EHR-based diagnosis might differ from prediction of a more rigorous diagnostic criterion. This distinction is important because EHR data are subject to multiple biases, including diagnostic misclassification and differential health care use resulting from factors such as illness severity.
Objective: This study aims to compare predictive models using the same predictors to predict an EHR-based versus semistructured interview-based PTSD diagnostic criterion, quantify model performance discrepancies, and examine potential mechanisms that account for performance differences.