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Article Abstract
Objective: To study into the genetic polymorphism of DC-SIGN and DC-SIGNR's exon 4 in Chinese hepatitis C patients and its relationship with HCV infection susceptibility.
Methods: Patients with hepatitis C (n=300, group A) and healthy subjects (n=520, group B) were genotyped and analysed for the repeat sequence of polymorphism of DC-SIGN and DC-SIGNR's exon 4 using PCR and DNA sequencing.
Results: The distribution of genotypes and alleles in DC-SIGN's exon 4 in the two groups did not differ significantly (P > 0.05). The difference of allele frequency in DC-SIGNR's exon 4 between the two groups was also not significant (P > 0.05). However, 9/5 genotype distribution frequency of DC-SIGNR's exon 4 in patients with hepatitis C was significantly higher than that in the healthy subjects (P < 0.05).
Conclusion: There is no significant correlation between the genetic polymorphism of DC-SIGN's exon 4 and HCV infection susceptibility. 9/5 genotype distribution frequency of DC-SIGNR's exon 4 in patients with hepatitis C is significantly higher and may be associated with HCV infection susceptibility.
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[Genetic polymorphism of dendritic cell-specific ICAM-3 grabbing nonintegrin and DC-SIGNR's exon 4 in Chinese hepatitis C patients].
Zhonghua Gan Zang Bing Za Zhi
December 2007
Shenzhen Donghu Hospital, Shenzhen, China.
Article Synopsis
- The study examined the genetic variations of DC-SIGN and DC-SIGNR's exon 4 in 300 hepatitis C patients compared to 520 healthy individuals to assess their relationship with susceptibility to HCV infection.
- Results showed no significant differences in the overall genotype and allele distributions of DC-SIGN, but a specific 9/5 genotype of DC-SIGNR was found to be more frequent in hepatitis C patients.
- The conclusion suggests that while DC-SIGN's exon 4 polymorphism is not linked to HCV susceptibility, the 9/5 genotype of DC-SIGNR may indicate a higher risk for hepatitis C infection.