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A 1xN interferometer-based router with single-stage all-pass filters in the arms has low loss, a flat passband, and low cross talk. However, we show that the router has substantial cubic dispersion over the channel passband, which is identical from channel to channel. For a 1x4 router with a free spectral range of 100 GHz, the average dispersion slope over a 60% passband is -8x10(3)ps/nm(2), and thus a cascade of four routers incurs a significant system power penalty. A three-stage all-pass filter placed on the input arm reduces the dispersion of all channels by a factor of 16. The router is quite insensitive to variations in the all-pass filter design parameters.
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http://dx.doi.org/10.1364/ol.27.001318 | DOI Listing |
Periodontol 2000
September 2025
Department of Periodontics and Oral Medicine, University of Michigan School of Dentistry, Ann Arbor, Michigan, USA.
This systematic review and meta-analysis aimed to evaluate the long-term clinical outcomes of regenerative procedures compared with access flap surgery for the treatment of intrabony defects, with a minimum follow-up period of 5 years. A systematic review protocol following PRISMA guidelines was conducted. Both electronic and manual searches were conducted to identify randomized clinical trials (RCTs) on regenerative treatment of deep intrabony defects (≥3 mm) with a follow-up of at least 5 years.
View Article and Find Full Text PDFVasc Specialist Int
September 2025
Department of Vascular Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
An abdominal aortic aneurysm (AAA) is defined as a localized dilation of the abdominal aorta measuring at least 1.5 times its normal diameter. If left untreated, AAA can progress to a life-threatening condition.
View Article and Find Full Text PDFJ Cachexia Sarcopenia Muscle
October 2025
Department of Surgery, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University, Maastricht, the Netherlands.
Background: Body composition alterations such as skeletal muscle (SM) loss in cancer patients are associated with poor survival. In turn, immune cell-driven pathways have been linked to muscle wasting. We aimed to investigate the relationship between body composition, tumour-infiltrating lymphocytes and survival in patients with advanced lung cancer.
View Article and Find Full Text PDFObesity (Silver Spring)
September 2025
Department of Nutrition Sciences, University of Alabama at Birmingham (UAB), Birmingham, Alabama, USA.
Objective: This secondary analysis was conducted to compare the magnitude of adaptive thermogenesis (AT) following hypocaloric low-carbohydrate (CHO) versus low-fat diets in African American (AA) women.
Methods: Sixty-nine AA women with obesity were randomized to low-CHO or low-fat hypocaloric diets for 10 weeks, followed by a 4-week weight stabilization period (all food provided). At baseline and Week 13, insulin sensitivity (S) was measured by intravenous glucose tolerance test, body composition by bioimpedance analysis, total energy expenditure (EE) (TEE) by doubly labeled water, and resting EE (REE) by indirect calorimetry.
Nature
September 2025
Department of Laboratory Medicine and Pathology, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada.
Cancer-associated muscle wasting is associated with poor clinical outcomes, but its underlying biology is largely uncharted in humans. Unbiased analysis of the RNAome (coding and non-coding RNAs) with unsupervised clustering using integrative non-negative matrix factorization provides a means of identifying distinct molecular subtypes and was applied here to muscle of patients with colorectal or pancreatic cancer. Rectus abdominis biopsies from 84 patients were profiled using high-throughput next-generation sequencing.
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