98%
921
2 minutes
20
Previous research suggests that motor equivalence is achieved through reliance on effector-independent spatiotemporal forms. Here the authors report a series of experiments investigating the role of such forms in the production of movement sequences. Participants were asked to complete series of arm movements in time with a metronome and, on some trials, with an obstacle between 1 or more of the target pairs. In moves following an obstacle, participants only gradually reduced the peak heights of their manual jumping movements. This hand path priming effect, scaled with obstacle height, was preserved when participants cleared the obstacle with 1 hand and continued with the other, and it was modulated by future task demands. The results are consistent with the hypothesis that the control of movement sequences relies on abstract spatiotemporal forms. The data also support the view that motor programming is largely achieved by changing just those features that distinguish the next movement to be made from the movement that was just made.
Download full-text PDF |
Source |
---|---|
http://dx.doi.org/10.1037/0096-1523.33.5.1117 | DOI Listing |
Cell
August 2025
Department of Cardiac Surgery, Jiangsu Provincial Key Laboratory of Critical Care Medicine, Zhongda Hospital, Key Laboratory of Developmental Genes and Human Disease, State Key Laboratory of Digital Medical Engineering, School of Biological Science and Medical Engineering, School of Life Science and
Early organogenesis is a crucial stage in embryonic development, characterized by extensive cell fate specification to initiate organ formation but also by a high susceptibility to developmental defects. Here, we profiled 285 serial sections from six E7.5-E8.
View Article and Find Full Text PDFJAMA Neurol
September 2025
Translational Neuropathology Research Laboratory, Department of Pathology and Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia.
Importance: Exposure to fine particulate matter air pollution (PM2.5) may increase risk for dementia. It is unknown whether this association is mediated by dementia-related neuropathologic change found at autopsy.
View Article and Find Full Text PDFJ Forensic Leg Med
September 2025
China People's Police University, Langfang, 065000, China.
Forensic identification at fire scenes faces three core challenges: distinguishing cause of death (antemortem burning versus postmortem corpse burning), reconstructing criminal behavior (arson versus accident), and preserving evidence (thermal destruction versus artificial tampering). This case study systematically demonstrates the application value of burn trace characteristics in arson investigation through a typical intentional homicide and corpse burning case. Based on a three-dimensional analytical framework of human burn-behavioral characteristics, a systematic pathway incorporating reconstruction of arson/corpse burning processes and identification of body relocation behavior was established.
View Article and Find Full Text PDFCell Rep
September 2025
Vascular Cell Biology Lab, Department of Medical Biochemistry, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands; Molecular Cell Biology Lab, Department of Molecular Hematology, Sanquin Research, and Landsteiner Laboratory, Amsterdam, the Netherlands; Leeuwenhoek Centre for Advanced
Upon inflammation, leukocytes extravasate through endothelial cells. When they extravasate, it is generally accepted that neighboring endothelial cells disconnect. Careful examination of endothelial junctions showed a partial membrane overlap beyond VE-cadherin distribution.
View Article and Find Full Text PDFBiomater Sci
September 2025
School of Medical Technology, Beijing Institute of Technology, Beijing 100081, China.
Cancer immunotherapy has transformed oncological treatment paradigms, yet tumor resistance and immune evasion continue to limit therapeutic efficacy. Mitochondria-targeting organic sensitizers (MTOSs) represent an emerging class of therapeutic agents that exploit mitochondrial dysfunction as a convergent node for tumor elimination and immune activation. As central regulators of cellular metabolism, apoptotic signaling, and immune cell function, mitochondria serve as critical determinants of tumor progression and the immunological landscape within the tumor microenvironment (TME).
View Article and Find Full Text PDF