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Systemic scleroderma can cause significant hand deformity and functional impairment. Surgery is often avoided due to the perceived risks of wound healing. The most common surgical procedures have been digital sympathectomy, arthrodesis or arthroplasty of the proximal interphalangeal (PIP) or both, and metacarpophalangeal (MCP) joints. We describe herein successful soft tissue hand surgery in 2 patients for treatment of scleroderma claw deformities without the use of arthrodesis or arthroplasty. At the MCP joint, the tight capsules were excised, and the collateral ligaments and volar plates were released. At the PIP joints, the volar plates were released and the tight palmar skin was released, resulting in marked improvement of joint position. Intensive hand therapy was used to maximize function. In these 2 patients with claw deformity, we found that tight volar skin was the main contributor to flexion contracture at the PIP level. In contrast, joint capsule contracture was the main contributor to hyperextension deformity at the MCP level.
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http://dx.doi.org/10.1016/j.jhsa.2007.06.011 | DOI Listing |
Eur J Trauma Emerg Surg
September 2025
Department of Surgery, Division of Trauma Surgery, University Medical Center Groningen, Groningen, The Netherlands.
Pediatr Surg Int
September 2025
Pediatric Surgery Unit, Department of Women's and Children's Health, University of Padua, Via Nicolò Giustiniani, 35100, Padua, Italy.
Introduction: Brachytherapy has been used for the multimodal treatment of pediatric bladder-prostate rhabdomyosarcoma in the last two decades. The aim of this systematic review is to gather the current evidence about this innovative technique with a special focus on long-term outcomes.
Methods: According to PRISMA criteria, PubMed, Scopus, and Web of Science were searched for papers published between 2000 and 2022.
Int Arch Occup Environ Health
September 2025
Department of Mechanical Engineering, Politecnico di Milano, Milan, Italy.
Purpose: To investigate the role of personal risk factors in the occurrence of the vascular, neurological and fibroproliferative disorders of the hand-arm vibration syndrome (HAVS) in workers groups exposed to hand-transmitted vibration (HTV).
Methods: HAVS prevalence and incidence data were pooled across a series of cross-sectional studies (total sample: 1272 HTV workers, 579 controls) and prospective cohort studies (total sample: 377 HTV workers, 138 controls) conducted in Central and North-Eastern Italy. The pooled studies included detailed individual-level information about HTV exposure, personal risk factors, medical comorbidities and HAVS disorders.
Nucleic Acids Res
September 2025
School of Biomedical and Pharmaceutical Sciences, Guangdong University of Technology, No. 100 Waihuanxi Road, Guangzhou 510006, China.
The 5' untranslated region (5'UTR) plays a crucial regulatory role in messenger RNA (mRNA), with modified 5'UTRs extensively utilized in vaccine production, gene therapy, etc. Nevertheless, manually optimizing 5'UTRs may encounter difficulties in balancing the effects of various cis-elements. Consequently, multiple 5'UTR libraries have been created, and machine learning models have been employed to analyze and predict translation efficiency (TE) and protein expression, providing insights into critical regulatory features.
View Article and Find Full Text PDFMinim Invasive Ther Allied Technol
September 2025
Department of Surgery, Yonsei University College of Medicine, Seoul, Korea.
Background: This pilot study investigates the adaptability of the articulating instrument (ArtiSential) among surgeons with different levels of experience in conventional laparoscopic surgery.
Methods: From June to November 2023, 18 laparoscopic surgeons participated in peg transfer and suture training using ArtiSential instruments. Participants were categorized into novice, intermediate, and expert groups.