Category Ranking

98%

Total Visits

921

Avg Visit Duration

2 minutes

Citations

20

Article Abstract

A synthesis of highly functionalized nitroalkenes is reported that utilizes a cross metathesis (CM) reaction between simple aliphatic nitro compounds and a range of substituted alkenes. This chemistry offers a simple and attractive route to nitroalkenes that would otherwise be difficult to prepare, and that have a very useful application as precursors to a variety of heterocyclic entities.

Download full-text PDF

Source
http://dx.doi.org/10.1021/ol070557kDOI Listing

Publication Analysis

Top Keywords

cross metathesis
8
efficient synthesis
4
synthesis nitroalkenes
4
nitroalkenes alkene
4
alkene cross
4
metathesis facile
4
facile access
4
access small
4
small ring
4
ring systems
4

Similar Publications

Thermoset Architecture Fusion Enabled by Catalyst-Free C═C/C═N Metathesis Chemistry.

J Am Chem Soc

September 2025

Institute of Sustainability for ChemicalsEnergy and Environment (ISCE), Agency for Science, Technology and Research (A*STAR), 1 Pesek Road, Singapore, Jurong Island 627833, Republic of Singapore.

Thermosets with permanent cross-linked structures provide excellent durability but pose significant challenges for reprocessing and recycling, raising engineering and environmental concerns as their usage expands. The advent of covalent adaptable networks (CANs) with dynamic covalent linkages has improved thermoset recyclability and enabled the fusion of identical polymer networks (A-A type fusion). However, fusing different thermosets (A-B type fusion) remains challenging due to their distinct dynamic behaviors and variable activation energies for bond exchange.

View Article and Find Full Text PDF

The absolute configurations of the polyketide fragment in the 12-membered macrolide HA 23 were initially proposed based on the "Biochemistry-based Rule" and subsequently confirmed through its first successful total synthesis. This synthesis, accomplished in 18 linear steps with an overall yield of 6.9%, featured key transformations including the Julia-Kocienski olefination, the Paterson -aldol reaction, and cross-metathesis.

View Article and Find Full Text PDF

-hydrazine cyclic(amino)(alkyl)carbene ruthenium complexes: synthesis and reactivity in olefin metathesis.

Chem Commun (Camb)

August 2025

Univ Rennes, École Nationale Supérieure de Chimie de Rennes, CNRS, ISCR UMR 6226, 35000 Rennes, France.

The synthesis of a ruthenium complex containing an -hydrazine cyclic(amino)(alkyl)carbene (CAAC) ligand is reported. This robust and air-stable complex demonstrates good to excellent catalytic performances under an air atmosphere in various ring-closing metathesis (RCM), ring-closing enyne metathesis (RCEYM), ring-opening cross-metathesis (ROCM), self-metathesis (SM), cross-metathesis (CM) and ethenolysis reactions.

View Article and Find Full Text PDF

Bioinspired catalysts replicate key catalytic functions of natural enzymes and offer innovative solutions to challenges in chemical synthesis, energy conversion, and environmental sustainability. In this study, bottlebrush polymers are synthesized via ring-opening metathesis polymerization (ROMP) and their use as bioinspired photocatalysts. By precisely controlling the degrees of polymerization, monomer composition and sequence, and the architecture of macromonomers, phenoxazine photosensitizer and/or bipyridine-nickel complexes are incorporated into bottlebrush polymers to afford photoredox and dual photocatalysts.

View Article and Find Full Text PDF

C-labeling of 20(S)-protopanaxadiol, an aglycon of ginsenoside, based on the use of Pd(0)-mediated rapid C-[C]methylation of boronic precursors.

Bioorg Med Chem Lett

December 2025

Department of Clinical and Experimental Neuroimaging, Center for Development of Advanced Medicine for Dementia, National Center for Geriatrics and Gerontology, 7-430 Morioka-cho, Obu-shi, Aichi 474-8511, Japan. Electronic address:

Ginsenosides, the pharmacologically active components of Panax ginseng, are widely used in herbal medicine and reportedly exert diverse biological effects, including anticancer, anti-inflammatory, and neuroprotective activities. However, their pharmacological mechanisms remain poorly understood, owing to the lack of chemical probes suitable for in vivo analyses. Herein, we report the development of a C radiolabeling of 20(S)-protopanaxadiol (PPD), a major aglycone-type active ginsenoside metabolite, for positron emission tomography (PET) imaging.

View Article and Find Full Text PDF