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A synthesis of highly functionalized nitroalkenes is reported that utilizes a cross metathesis (CM) reaction between simple aliphatic nitro compounds and a range of substituted alkenes. This chemistry offers a simple and attractive route to nitroalkenes that would otherwise be difficult to prepare, and that have a very useful application as precursors to a variety of heterocyclic entities.
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http://dx.doi.org/10.1021/ol070557k | DOI Listing |
J Am Chem Soc
September 2025
Institute of Sustainability for ChemicalsEnergy and Environment (ISCE), Agency for Science, Technology and Research (A*STAR), 1 Pesek Road, Singapore, Jurong Island 627833, Republic of Singapore.
Thermosets with permanent cross-linked structures provide excellent durability but pose significant challenges for reprocessing and recycling, raising engineering and environmental concerns as their usage expands. The advent of covalent adaptable networks (CANs) with dynamic covalent linkages has improved thermoset recyclability and enabled the fusion of identical polymer networks (A-A type fusion). However, fusing different thermosets (A-B type fusion) remains challenging due to their distinct dynamic behaviors and variable activation energies for bond exchange.
View Article and Find Full Text PDFOrg Lett
August 2025
State Key Laboratory of Chemical Oncogenomics, Peking University Shenzhen Graduate School, Shenzhen 518055, China.
The absolute configurations of the polyketide fragment in the 12-membered macrolide HA 23 were initially proposed based on the "Biochemistry-based Rule" and subsequently confirmed through its first successful total synthesis. This synthesis, accomplished in 18 linear steps with an overall yield of 6.9%, featured key transformations including the Julia-Kocienski olefination, the Paterson -aldol reaction, and cross-metathesis.
View Article and Find Full Text PDFChem Commun (Camb)
August 2025
Univ Rennes, École Nationale Supérieure de Chimie de Rennes, CNRS, ISCR UMR 6226, 35000 Rennes, France.
The synthesis of a ruthenium complex containing an -hydrazine cyclic(amino)(alkyl)carbene (CAAC) ligand is reported. This robust and air-stable complex demonstrates good to excellent catalytic performances under an air atmosphere in various ring-closing metathesis (RCM), ring-closing enyne metathesis (RCEYM), ring-opening cross-metathesis (ROCM), self-metathesis (SM), cross-metathesis (CM) and ethenolysis reactions.
View Article and Find Full Text PDFSmall
August 2025
Department of Chemistry, The University of Chicago, 929 E 57th Street, Chicago, IL, 60637, USA.
Bioinspired catalysts replicate key catalytic functions of natural enzymes and offer innovative solutions to challenges in chemical synthesis, energy conversion, and environmental sustainability. In this study, bottlebrush polymers are synthesized via ring-opening metathesis polymerization (ROMP) and their use as bioinspired photocatalysts. By precisely controlling the degrees of polymerization, monomer composition and sequence, and the architecture of macromonomers, phenoxazine photosensitizer and/or bipyridine-nickel complexes are incorporated into bottlebrush polymers to afford photoredox and dual photocatalysts.
View Article and Find Full Text PDFBioorg Med Chem Lett
December 2025
Department of Clinical and Experimental Neuroimaging, Center for Development of Advanced Medicine for Dementia, National Center for Geriatrics and Gerontology, 7-430 Morioka-cho, Obu-shi, Aichi 474-8511, Japan. Electronic address:
Ginsenosides, the pharmacologically active components of Panax ginseng, are widely used in herbal medicine and reportedly exert diverse biological effects, including anticancer, anti-inflammatory, and neuroprotective activities. However, their pharmacological mechanisms remain poorly understood, owing to the lack of chemical probes suitable for in vivo analyses. Herein, we report the development of a C radiolabeling of 20(S)-protopanaxadiol (PPD), a major aglycone-type active ginsenoside metabolite, for positron emission tomography (PET) imaging.
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