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Two new iridoids 6-O-[2,3-dimethoxy]-trans-cinnamoyl catalpol (1) and 6-O-meta-methoxy-benzoyl catalpol (2) along with a known iridoid picroside 1 (3), two stilbenes quadrangularin A (4) and pallidol (5), quercitin (6), quercitrin (7), beta-sitosterol (8) and beta-sitosterol glycoside (9) were isolated from Cissus quadrangularis Linn. The compounds 3 and 7 are first reported from this plant. The structures were elucidated by analysis of their spectroscopic data and by direct comparison with literature. This is the first reported occurrence of iridoids in C. quadrangularis.
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http://dx.doi.org/10.1080/14786410601130471 | DOI Listing |
Discov Nano
September 2025
Department of Conservative Dentistry and Endodontics, SRM Kattankulathur Dental College and Hospital, SRM Institute of Science and Technology, Chengalpattu, Tamil Nadu, 603203, India.
This study focuses on tripartite synthesis of Silver (AgNPs), Mesoporous Silica (MSNs), and Hydroxyapatite (n-HAp) nanoparticles with aqueous extract of Cissus quadrangularis (Veldt grape plant; Indian name: Pirandai) as a reducing agent. The dried and powdered form of the plant was subjected to aqueous extraction. The phytochemicals analysis was qualitatively estimated which detected the presence of alkaloid, tannin, phenol, terpenoid, steroid and saponin.
View Article and Find Full Text PDFJ Ethnopharmacol
August 2025
Ethnopharmacology Laboratory, Department of Botany (DST-FIST and UGC-DRS SAP-II), Visva-Bharati University, Santiniketan, 731235, India. Electronic address:
Ethnopharmacological Relevance: The Mahali is a marginalized ethnic group in eastern India who primarily relies on the local medicinal flora and fauna for their healthcare needs. Their extensive knowledge of medicinal species has largely gone unrecognized for centuries. The forces of modernization and cultural infiltration pose a significant risk of eroding this invaluable treasure of knowledge over time.
View Article and Find Full Text PDFAppl Biochem Biotechnol
July 2025
A Laboratório de Bioinformática e Química Medicinal (LABIOQUIM), Fundação Oswaldo Cruz Rondônia, Porto Velho, RO, Brazil.
In the twenty-first century, across the world, there are few ethnomedical solutions for treating type 2 diabetes mellitus (T2DM), a common metabolic disease and its associated disorders. The present study assessed the hypoglycaemic effects of an extract from the stem of Cissus quadrangularis in a rat model with the addition of in vitro and in silico investigations specifically α-amylase, α-glucosidase inhibitory tests and molecular docking, molecular dynamics (MD) simulation study. Streptozotocin and nicotinamide were used to generate type 2 diabetes in rats.
View Article and Find Full Text PDFBMC Complement Med Ther
July 2025
Department of Pharmacology, Faculty of Medicine, Chiang Mai University, Chiang Mai, 50200, Thailand.
Background: Maintaining bone health is vital, particularly for aging populations prone to bone disorders. Cissus quadrangularis (CQ), a traditional medicinal plant, is increasingly recognized for its potential benefits in promoting bone health, including the effects on bone-related biomarkers promoting bone healing and bone density improvement. This study aimed to evaluate the effects of CQ on bone-related biomarkers in humans as the primary objective and to assess its impact on other clinical outcomes as a secondary objective.
View Article and Find Full Text PDFFront Plant Sci
June 2025
Department of Horticulture and Food Science, VIT School of Agricultural Innovations and Advanced Learning, Vellore Institute of Technology, Vellore, Tamil Nadu, India.
, commonly known as veldt grape, is an underutilized medicinal plant belonging to the Vitaceae family, widely found in tropical regions of India with diverse populations. The plant is also known for its rich phytochemical profile, including ketosteroids and flavonoids that enhance osteoblast activity and accelerate fracture healing. Also, this genus is unique in having a high degree of drought tolerance due to its facultative crassulacean acid metabolism (CAM) pathway.
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