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Diabetic ketoacidosis (DKA) may be present at the onset of type 1 diabetes (T1D), increasing both its morbidity and mortality. The aim of this study was to describe the frequency of this complication at the clinical presentation of T1D, as well as possible interfering factors in a multi-ethnic population from Brazil. We have reviewed the medical charts of 545 individuals with T1D diagnosed between 1968 and 2006 from two major local diabetes treatment centers. DKA occurred in 179 patients (32.8%) at the onset of T1D. The frequency of DKA was higher in non-white than white individuals (p<0.0001) and in the younger age groups (
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http://dx.doi.org/10.1016/j.diabres.2007.04.002 DOI Listing Publication Analysis
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Diabetes Res Clin Pract
September 2025
Université Paris Cité, ECEVE, UMR 1123, Inserm, F-75010 Paris, France; Assistance Publique-Hôpitaux de Paris, Hôpital Robert Debré, Service de santé publique, équipe REPERES, F-75019 Paris, France. Electronic address:
Aims: To study the association between socioeconomic status (SES) and hospital efficiency in Type 1 diabetes mellitus patients admitted for ketoacidosis or diabetic coma in mainland France, overall and in adults versus children.
Methods: An observational study was carried out using exhaustive national hospital discharge databases. It included all admissions discharged from 2013 to 2019.
Ann Emerg Med
September 2025
Division of Emergency Medicine, Department of Medicine, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada; Lawson Health Research Institute, London Health Sciences Centre, London, ON, Canada.
Study Objective: We conducted a systematic review and meta-analysis to evaluate the safety and efficacy of the two-bag versus one-bag method in diabetic ketoacidosis (DKA) management in adult and pediatric populations.
Methods: The study was registered with the Prospective Register of Systematic Reviews, in adherence to Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. A search was conducted across MEDLINE, EMBASE, and CENTRAL databases up to March 2025, with no restrictions on study design.
Cureus
August 2025
Department of Medicine, Bangladesh Institute of Health Sciences (BIHS) General Hospital, Dhaka, BGD.
Objective: Type 2 diabetes mellitus (T2DM) is a chronic metabolic disorder frequently associated with obesity, leading to increased risks of cardiovascular and renal complications. Dapagliflozin, a sodium-glucose cotransporter-2 (SGLT2) inhibitor, has emerged as a promising therapeutic agent for improving glycemic control and promoting weight reduction. However, evaluating its safety and efficacy in obese T2DM patients remains essential, particularly in real-world clinical settings.
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September 2025
Department of Emergency Medicine, Children's Minnesota, Minneapolis, Minnesota.
Objectives: The 2-bag intravenous (IV) fluid system for diabetic ketoacidosis (DKA) has been associated with shorter duration of insulin and faster resolution of acidosis. Our aims were to increase the use of 2-bag IV fluids among children with medium- or high-risk DKA treated at 2 tertiary care pediatric hospitals and to increase the proportion of children who receive timely administration of fluid and insulin treatments.
Methods: We conducted a quality improvement initiative using data from January 1, 2014, to December 31, 2021, among patients 21 years or younger with medium- or high-risk DKA.
Diabetes Obes Metab
September 2025
Division of Endocrinology and Metabolism, Department of Medicine, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.
Aims: To determine the effectiveness and safety of early combination therapy with insulin degludec and intravenous insulin infusion (IVII) compared with IVII alone in diabetic ketoacidosis (DKA) management.
Materials And Methods: This prospective, open-label, randomised controlled trial included 80 adults (≥18 years) with DKA. Participants were randomised to either the intervention group, which received early subcutaneous (SC) insulin degludec (0.