Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Early studies identified the CC-chemokine receptor (CCR)7 as an important homing molecule controlling the lymph node entry of naive T cells through high endothelial venules and of activated mature dendritic cells through afferent lymphatics. Consequently, these properties initially branded CCR7 as a central organizer of the primary immune response. However, recent studies have demonstrated that a variety of immune cells crucially rely on CCR7-directed migration not only for the induction of protective immunity but also for the establishment of immunological tolerance. In this review, we therefore highlight some of the recent advances in understanding the multiple roles of CCR7 in the induction and maintenance of central and peripheral tolerance.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.it.2007.04.002 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Cortical response to transient and long-term visual field loss.
Cereb Cortex
August 2025
Nencki Institute of Experimental Biology, PAS, 3 Pasteur Street, 02-093 Warsaw, Poland.
In the visual cortices, receptive fields (RFs) are arranged in a gradient from small sizes in the center of the visual field to the largest sizes at the periphery. Using functional magnetic resonance imaging (fMRI) mapping of population RFs, we investigated RF adaptation in V1, V2, and V3 in patients after long-term photoreceptor degeneration affecting the central (Stargardt disease [STGD]) and peripheral (Retinitis Pigmentosa [RP]) regions of the retina. In controls, we temporarily limited the visual field to the central 10° to model peripheral loss.
View Article and Find Full Text PDFThe nature of fatigue in amyotrophic lateral sclerosis: a systematic review and meta-analysis.
Acta Neurol Belg
September 2025
Neuroscience Research Australia, University of New South Wales, Sydney, Australia.
Objectives: Patients diagnosed with amyotrophic lateral sclerosis (ALS) typically describe symptoms of fatigue. Despite this frequency, the underlying mechanisms of fatigue are poorly understood, and are likely multifactorial. To help clarify mechanisms, the present systematic review was undertaken to determine the risk factors related to fatigue in ALS.
View Article and Find Full Text PDFExploring LRP-1 in the liver-brain axis: implications for Alzheimer's disease.
Mol Biol Rep
September 2025
Department of Pharmacology, Govt. College of Pharmacy, Rohru, Shimla, Himachal Pradesh, 171207, India.
Alzheimer's disease (AD) is the most common, complex, and untreatable form of dementia which is characterized by severe cognitive, motor, neuropsychiatric, and behavioural impairments. These symptoms severely reduce the quality of life for patients and impose a significant burden on caregivers. The existing therapies offer only symptomatic relief without addressing the underlying silent pathological progression.
View Article and Find Full Text PDFAbnormal Puberty and Amenorrhea: A Review.
Pediatr Ann
September 2025
Reproductive Medicine Associates of New Jersey, IVIRMA Global, Basking Ridge, New Jersey.
Puberty marks the development of secondary sexual characteristics and reproductive capacity, with normal onset ranging from age 8 to 13 years in female children. Precocious puberty (ie, the onset of secondary sexual characteristics before age 8 years in female children) can result from central or peripheral mechanisms, requiring tailored diagnostic and therapeutic approaches. Delayed puberty (ie, the absence of sexual development beyond expected age ranges) often stems from primary or secondary hypogonadism.
View Article and Find Full Text PDFThe thermal grill elicits central sensitization.
Pain
August 2025
Centre for Multimodal Sensorimotor and Pain Research, Faculty of Dentistry, University of Toronto, Toronto, ON, Canada.
The thermal grill, in which innocuous warm and cool stimuli are interlaced, can produce a paradoxical burning pain sensation-the thermal grill illusion (TGI). Although the mechanisms underlying TGI remain unclear, prominent theories point to spinal dorsal horn integration of innocuous thermal inputs to elicit pain. It remains unknown whether the TGI activates peripheral nociceptors, or solely thermosensitive afferents that are integrated within the spinal cord to give rise to a painful experience.
View Article and Find Full Text PDF