Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Using DNA heteroduplex tracking assays, we characterized human immunodeficiency virus type 1 env V4/V5 genetic populations in multiple blood plasma samples collected over an average of 7 months from 24 chronically infected human subjects. We observed complex and dynamic V4/V5 genetic populations in most subjects. Comparisons of V4/V5 and V1/V2 population changes over the course of the study showed that major shifts in genetic populations frequently occurred in one region but not the other, and these observations were independently confirmed in one subject by single-genome sequencing. These results suggest that the V1/V2 and V4/V5 regions of env often evolve independently during chronic infection.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1900199 | PMC |
| http://dx.doi.org/10.1128/JVI.02554-06 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
The role of Denisovan paleohabitats in shaping modern human genetic resistance to viral, bacterial, and parasitic infections.
J Hum Evol
September 2025
Sustainability Solutions Research Lab, University of Pannonia, Egyetem utca 10, H-8200, Veszprém, Hungary. Electronic address:
Denisovans contributed notably to the genomes of present-day East and Southeast Asians. However, the relationship between the inhabited paleohabitats and the adaptive genetic traits related to infections in modern humans remains underexplored. This study uses geospatial techniques to analyze climatic factors associated with three Denisovan archaeological sites linked to nine specimens.
View Article and Find Full Text PDFMetabolic Flexibility in Insects: Patterns, Mechanisms, and Implications.
Annu Rev Entomol
September 2025
2Department of Animal Physiology, Zoological Institute and Museum, University of Greifswald, Greifswald, Germany.
The evolutionary success of insects may be partly attributed to their profound ability to adjust metabolism in response to environmental stress or resource variability at a range of timescales. Metabolic flexibility encompasses the ability of an organism to adapt or respond to conditional changes in metabolic demand and tune fuel oxidation to match fuel availability. Here, we evaluate the mechanisms of metabolic flexibility in insects that are considered short-term, medium-term, and long-term responses.
View Article and Find Full Text PDFGenomic analysis of the in Taiwan: a nationwide study from 2006 to 2022.
Microb Genom
September 2025
National Institute of Infectious Diseases and Vaccinology, National Health Research Institutes, Zhunan, Taiwan, ROC.
remains a leading respiratory pathogen for children and the elderly. In Taiwan, a national PCV13 catch-up vaccination programme for children began in March 2013. This study investigates the population structure and antimicrobial profiles of pneumococcal isolates in Taiwan from 2006 to 2022.
View Article and Find Full Text PDFCathepsin Z is a conserved susceptibility factor underlying tuberculosis severity.
PLoS Biol
September 2025
Department of Molecular Genetics and Microbiology, Duke University, Durham, North Carolina, United States of America.
Tuberculosis (TB) outcomes vary widely, from asymptomatic infection to mortality, yet most animal models do not recapitulate human phenotypic and genotypic variation. The genetically diverse Collaborative Cross mouse panel models distinct facets of TB disease that occur in humans and allows identification of genomic loci underlying clinical outcomes. We previously mapped a TB susceptibility locus on mouse chromosome 2.
View Article and Find Full Text PDFNeonatal diabetes: 20-year experience from a tertiary care pediatric diabetes clinic in north India.
Horm Res Paediatr
September 2025
Background: Neonatal diabetes mellitus (NDM) is a rare monogenic disorder, typically diagnosed within the first six months of life. While NDM is well-recognized globally, data from India regarding its clinical characteristics, treatment strategies, and long-term outcomes are scarce.
Objectives: To describe the molecular characterization, clinical phenotype and follow-up of children with NDM.