Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
CH(2)Cl(2) fraction obtained from the stem bark of Mammea africana inhibited noradrenaline (NA) or KCl-induced contraction in isolated guinea pig and rat aorta. The vasorelaxant potency of the CH(2)Cl(2) fraction of Mammea africana was diminished by a pre-treatment with Nitro-L-arginine methyl ester (L-NAME), an inhibitor of NO synthase, which was however not affected by indomethacin pre-treatment. These findings indicated that the vasorelaxant effect of Mammea africana may be partially endothelium dependent, mediated by nitric oxide and that vasoactive prostanoids might not be contributing to the vasorelaxation effect. Three bioactive compounds were isolated from this CH(2)Cl(2) fraction and identified as 4-n-propylcoumarins (1) (mammea B/BB), 4-phenylcoumarins (2) (mammea A/AA or mammeisin) and (B/BA) (3) and might involved in the vasorelaxant effect of the extract. The mechanisms of the vasorelaxant effect might therefore be multiple, including endothelium dependence and the mechanisms, which interfere with the liberation of Ca(2+) into the muscle cell.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.jep.2006.11.026 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Hepatoprotective activity of Mammea africana ethanol stem bark extract.
Avicenna J Phytomed
May 2016
Department of Pharmacology and Toxicology Faculty of Pharmacy, University of Uyo, Uyo, Nigeria.
Objective: The stem bark of Mammea africana Sabine (Guttiferae), (M. africana) a common plant that has been traditionally used to treat various diseases and ailments was evaluated for hepatoprotective potentials against paracetamol-induced liver injury in rats.
Materials And Methods: The hepatoprotective effect of the stem bark extract (30-90 mg/kg) was evaluated by the assay of liver function parameters, namely total and direct bilirubin, serum protein and albumin, total cholesterol, alanine aminotransaminase (ALT), aspartate aminotransaminase (AST), and alkaline phosphatase activities (ALP), antioxidant enzymes: superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), reduced glutathione (GSH) and histopathological study of the liver.
Antibacterial and cytotoxic activity of isoprenylated coumarin mammea A/AA isolated from Mammea africana.
J Ethnopharmacol
May 2013
Department of Nutrition and Food Science, Wayne State University, Detroit, MI 48202, USA.
Ethnopharmacological Relevance: The stem bark of Mammea africana is widely distributed in tropical Africa and commonly used in traditional medicine. This study aims to identify the active compound in Mammea africana and to evaluate its antimicrobial and antiproliferative activity.
Materials And Methods: Methanol extract from the bark of the Mammea africana was separated by liquid-liquid extraction, followed by open column chromatography.
Endothelium/Nitric Oxide Mediates the Vasorelaxant and Antihypertensive Effects of the Aqueous Extract from the Stem Bark of Mammea africana Sabine (Guttiferae).
Evid Based Complement Alternat Med
September 2012
Laboratory of Animal Physiology and Phytopharmacology, Department of Animal Biology, University of Dschang, P.O. Box 67, Dschang, Cameroon.
This study evaluates the vasorelaxant and antihypertensive effects of the aqueous extract from the stem bark of M. africana (AEMA). AEMA was tested in vitro on intact or endothelium-denuded rats' aorta rings precontracted with KCl or norepinephrine in absence or in presence of L-NAME or glibenclamide.
View Article and Find Full Text PDFRenal effects of Mammea africana Sabine (Guttiferae) stem bark methanol/methylene chloride extract on L-NAME hypertensive rats.
Indian J Pharmacol
August 2010
Laboratory of Animal Physiology, Department of Animal Biology and Physiology, University of Yaounde I, P.O.Box 812 Yaounde, Cameroon.
Objective: The present study aims at evaluating the effects of methanol/methylene chloride extract of the stem bark of Mammea africana on the renal function of L-NAME treated rats.
Material And Methods: Normotensive male Wistar rats were divided into five groups respectively treated with distilled water, L-NAME (40 mg/kg/day), L-NAME + L-arginine (100 mg/kg/day), L-NAME + captopril (20 mg/kg/day) or L-NAME + M. africana extract (200 mg/kg/day) for 30 days.
Hypoglycaemic effects of Mammea africana (Guttiferae) in diabetic rats.
J Ethnopharmacol
February 2010
Department of Animal Biology and Physiology, Faculty of Science, University of Yaounde 1, PO Box 812, Yaounde, Cameroon.
Aim Of The Study: The stem bark of Mammea africana Sabine (Guttiferae) is used in African rain forest to treat various diseases, including diabetes mellitus. We investigated whether Mammea africana extract induced hypoglycaemic activity in rats.
Materials And Methods: We tested the effects of acute (5h) and sub-acute (21 days) oral administrations of the CH(2)Cl(2)-MeOH stem bark extract of Mammea africana (19-300 mg/kg body weight) on blood glucose levels of normal and streptozotocin (STZ)-induced type 1 diabetic rats.