Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Mitochondrial dysfunction is involved in the development of aging. Here, we examined the effect of aging on the skeletal muscle expression of two isoforms of the transcriptional peroxisome proliferator-activated receptor gamma (PPARgamma) coactivator-1 (PGC-1) in an experimental murine model of accelerated aging, the senescence-accelerated mouse (SAM). The senescence-accelerated prone mice (SAM-P8) showed no changes in PGC-1alpha, but a decrease in PGC-1beta expression (52% reduction, p <.001) was observed compared to the senescence-accelerated resistant mice (SAM-R1). In agreement with the proposed role of PGC-1beta as an estrogen-related receptor (ERR) protein ligand, the expression of the ERRalpha target gene medium-chain acyl-coenzyme A dehydrogenase was strongly suppressed (85%, p <.001) in SAM-P8. The decrease in the expression of medium-chain acyl-coenzyme A dehydrogenase was consistent with the reduction in ERRalpha DNA-binding activity of SAM-P8. These findings indicate that the age-mediated decrease in PGC-1beta expression in SAM-P8 skeletal muscle affects the expression of genes involved in mitochondrial fatty acid oxidation.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1093/gerona/61.8.773 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Construct prediction models for low muscle mass with metabolic syndrome using machine learning.
PLoS One
September 2025
Neck-Shoulder and Lumbocrural Pain Hospital of Shandong First Medical University, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, China.
Background: Metabolic syndrome (MetS) and sarcopenia are major global public health problems, and their coexistence significantly increases the risk of death. In recent years, this trend has become increasingly prominent in younger populations, posing a major public health challenge. Numerous studies have regarded reduced muscle mass as a reliable indicator for identifying pre-sarcopenia.
View Article and Find Full Text PDFVasoconstrictor responsiveness in resting and contracting skeletal muscle following an acute bout of exercise: Impact of aging.
J Appl Physiol (1985)
September 2025
Department of Physical Therapy and Rehabilitation Science, Carver College of Medicine, University of Iowa, Iowa City, Iowa.
Long-term exercise training can attenuate sympathetic vasoconstriction in both resting and contracting skeletal muscle; however, the impact of an acute bout of exercise on vasoconstrictor responsiveness and the influence of aging is unknown. Therefore, we tested the hypothesis that an acute bout of exercise will blunt sympathetic-mediated vasoconstriction in resting and contracting skeletal muscle of young and older adults. Twenty-one adults (10 Young: 23±5 yr and 11 Older: 65±8 yr) performed a rest and a rhythmic handgrip exercise trial before and after either 30 minutes of cycling exercise (60-65% HRmax) or a time control period (seated rest).
View Article and Find Full Text PDFSpindle Cell Spindle Sarcoma Harboring a Novel Gene Fusion.
Int J Surg Pathol
September 2025
Department of Pathology, The Thirteenth People's Hospital of Chongqing, Chongqing, China.
Soft tissue sarcomas are a heterogeneous group of malignancies arising from mesenchymal cells. Recent advancements in genomic profiling have identified novel gene fusions in these tumors, offering new insights into their pathogenesis and potential therapeutic targets. Here, we describe a spindle cell sarcoma harboring a novel gene fusion.
View Article and Find Full Text PDFNeural models and algorithms for sensorimotor control of an octopus arm.
Biol Cybern
September 2025
Department of Mechanical Science and Engineering, University of Illinois Urbana-Champaign, 61801, IL, USA.
In this article, a biophysically realistic model of a soft octopus arm with internal musculature is presented. The modeling is motivated by experimental observations of sensorimotor control where an arm localizes and reaches a target. Major contributions of this article are: (i) development of models to capture the mechanical properties of arm musculature, the electrical properties of the arm peripheral nervous system (PNS), and the coupling of PNS with muscular contractions; (ii) modeling the arm sensory system, including chemosensing and proprioception; and (iii) algorithms for sensorimotor control, which include a novel feedback neural motor control law for mimicking target-oriented arm reaching motions, and a novel consensus algorithm for solving sensing problems such as locating a food source from local chemical sensory information (exogenous) and arm deformation information (endogenous).
View Article and Find Full Text PDFAutomated volumetric MRI quantification of body fat and skeletal muscle in the UK Biobank: technical validation against expert manual segmentations and comparison with single-slice techniques.
Abdom Radiol (NY)
September 2025
Research Centre for Optimal Health, School of Life Sciences, University of Westminster, London, UK.
Objectives: The escalating global incidence of obesity, cardiometabolic disease and sarcopenia necessitates reliable body composition measurement tools. MRI-based assessment is the gold standard, with utility in both clinical and drug trial settings. This study aims to validate a new automated volumetric MRI method by comparing with manual ground truth, prior volumetric measurements, and against a new method for semi-automated single-slice area measurements.
View Article and Find Full Text PDF