Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
The present study was aimed to evaluate a liposomal formulation of amiloride on experimental seizure models including the increasing current electroshock seizure threshold test (ICES), pentylenetetrazole (PTZ)-induced seizures and PTZ-induced status epilepticus in mice. Further, the effect of liposomal amiloride on serum K(+) levels was also investigated using flame photometry. We found an improved anticonvulsant action with liposome-entrapped amiloride as compared to free amiloride. Further, free amiloride showed an increase in serum K(+) levels, however the latter was unaffected with liposomal formulation treatment. These results, together with previously published data, suggest that as drug delivery vehicles, liposomes can enhance the effectiveness of drugs in the CNS without producing peripheral toxicity (hyperkalemia).
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.euroneuro.2006.05.003 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Phospholipase A from venom induces acute kidney injury: involvement of ion channels in an isolated perfused rabbit kidney model.
J Venom Anim Toxins Incl Trop Dis
August 2025
Queen Saovabha Memorial Institute, Thai Red Cross Society, Pathumwan, Bangkok, Thailand.
Background: Acute kidney injury (AKI) is a serious complication associated with envenomation, primarily due to direct nephrotoxicity. This study aimed to investigate the effects of the phospholipase A (RvPLA₂) fraction from venom on renal function and to assess whether pretreatment with ion channel blockers could mitigate these effects using an isolated perfused kidney (IPK) model.
Methods: Twenty IPKs were allocated into five groups (n = 4 each): (1) RvPLA₂ in calcium-deficient modified Krebs-Henseleit solution (MKHS), (2) RvPLA₂ in standard MKHS, (3) RvPLA₂ following pretreatment with verapamil (a voltage-gated Ca²⁺ channel blocker), (4) RvPLA₂ following pretreatment with amiloride (a Na⁺ channel blocker), and (5) RvPLA₂ following pretreatment with minoxidil (a KATP channel opener).
A mechanistic investigation of the effects of lactic acidosis on myocardial contractility in the Neotropical fast-swimming freshwater fish Brycon amazonicus.
Comp Biochem Physiol C Toxicol Pharmacol
November 2025
Department of Physiological Sciences, Federal University of São Carlos (UFSCar), Via Washington Luis km 235, 13565-905 São Carlos, SP, Brazil. Electronic address:
Lactic acidosis commonly impairs myocardial contractility in vertebrates, limiting cardiac performance under metabolic stress. However, the rheophilic Neotropical species matrinxã (Brycon amazonicus) appears to exhibit physiological adaptations that support cardiac resilience. In this study, ventricular muscle strips were exposed to extracellular lactic acidosis (LA, 22 mM lactic acid, pH 6.
View Article and Find Full Text PDFNasal potential difference in young children is feasible - Report from a national referral center.
Respir Med
June 2025
Electrophysiology Laboratory, CF Center, Hadassah Hebrew University Medical Center, Jerusalem, Israel. Electronic address:
Background: -Nasal Potential Difference (NPD) is an established diagnostic tool for CF. However, standardized values for very young patients are lacking.
Aim: - To evaluate the feasibility of performing NPD testing in young children.
Involvement of Cholinergic and Cyclooxygenase Pathways in the Diuretic Effects of Rosmarinic Acid.
Chem Biodivers
March 2025
Programa de Pós-Graduação em Ciências Farmacêuticas, Universidade do Vale do Itajaí, 88302-901 -, Itajaí, Santa Catarina, Brasil.
Rosmarinic acid (RA) is a natural antioxidant known for its diverse biological activities. Although its diuretic activity has been previously established, the mode of action remained unclear. To investigate this, we examined the diuretic activity of RA alone and in combination with hydrochlorothiazide (HCTZ), amiloride (AML), atropine (ATR), and indomethacin (INDO) to see if any of these drugs could interfere with RA's activity in an 8 hour acute diuresis animal model.
View Article and Find Full Text PDFEvaluation of the translation of multiple cardiovascular regulatory mechanisms in the anesthetized dog.
J Pharmacol Toxicol Methods
March 2024
AbbVie Inc., 1 North Waukegan Rd., North Chicago, IL 60064, United States of America.
The strategic and targeted use of an anesthetized canine cardiovascular model early in drug discovery enables a comprehensive cardiovascular and electrophysiological assessment of potential safety liabilities and guides compound selection prior to initiation of chronic toxicological studies. An ideal model would enable exposure-response relationships to guide safety margin calculations, have a low threshold to initiate, and have quick delivery of decision quality data. We have aimed to profile compounds with diverse mechanism of actions (MoAs) of "non-QT" cardiovascular drug effects and evaluate the ability of nonclinical in vivo cardiovascular models to detect clinically reported effects.
View Article and Find Full Text PDF