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http://dx.doi.org/10.1002/cbic.200500478 | DOI Listing |
J Proteome Res
September 2025
State Key Laboratory of Medical Proteomics, Beijing Proteome Research Center, National Center for Protein Sciences (Beijing), Research Unit of Proteomics & Research and Development of New Drug of Chinese Academy of Medical Sciences, Institute of Lifeomics, Beijing 102206, China.
Hepatocellular carcinoma (HCC) constitutes approximately 90% of liver cancers, yet its early detection remains challenging due to the low sensitivity of current diagnostic methods and the difficulty in identifying minimal cancer cells within the body. This study employed a patient-derived xenograft (PDX) mouse model to screen for biomarkers, leveraging its advantage of low background interference compared to human serum exosome studies. Using a novel microextraction technique, exosomes were isolated from just one microliter of serum from HCC PDX mice, followed by proteomic profiling.
View Article and Find Full Text PDFJ Am Chem Soc
September 2025
Department of Chemistry, National Taiwan University, Taipei 106319, Taiwan.
The exclusive formation of artificial multicomponent assemblies remains a significant challenge, in contrast to the well-established organization observed in natural systems, due to intrinsic entropic constraints. To overcome this limitation, recent efforts have been focused on developing precision self-assembly strategies for the rational construction of such architectures. Here, we construct an ideal complementary pair of 2,2':6',2″-terpyridine (tpy)-based ligands by fine-tuning the substituent bulkiness, which enables the quantitative formation of robust nested cages through efficient dynamic heteroleptic complexation with multivalent coordination.
View Article and Find Full Text PDFAngew Chem Int Ed Engl
September 2025
College of Chemistry, Zhengzhou University, 100 Kexue Street, Zhengzhou, 450001, China.
Achieving quantitative control over interlayer spacing in multilayer two-dimensional (2D) supramolecular organic frameworks (SOFs) remains a fundamental challenge. Here, we report a molecular pillar engineering strategy enabling programmable vertical expansion of bilayer architectures. By designing elongated bipyridine pillars L2/L3 (3.
View Article and Find Full Text PDFJ Am Chem Soc
September 2025
Key Laboratory of Catalysis and Energy Materials Chemistry of Ministry of Education & Hubei Key Laboratory of Catalysis and Materials Science, South-Central Minzu University, Wuhan 430074, China.
In contrast to metal ions that have been routinely used to construct metal-organic frameworks (MOFs), anions have rarely been used as essential coordination centers in supramolecular organic frameworks (SOFs). In this work, we present a SOF, , based on the coordination of chloride anions and a flexible oligopyrrole. Owing to the multiple interactions between individual oligopyrrole molecules and an A-B-C-style stacking of the 2D honeycomb layers, crystalline exhibits reasonable thermal stability and retains its structure upon desolvation.
View Article and Find Full Text PDFACS Appl Mater Interfaces
September 2025
State Key Laboratory of Chemical Resource Engineering, Beijing 100029, China.
Circularly polarized luminescence (CPL) has emerged as a critical technology for anticounterfeiting and optical display applications due to its unique chiroptical properties. We report a multicolor CPL-emitting elastomeric film (P37/PSK@SiO-PDMS) that synergistically combines chiral helical polyacetylene (P37) and a surface-engineered perovskite (PSK@SiO) through hydrogen-bond-directed assembly. Confinement within the PDMS matrix drives P37 to self-assemble into a chiral supramolecular structure through hydrogen bonding, inducing a chiroptical inversion.
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