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Article Synopsis
- The administration of intermittent parathyroid hormone (iPTH) stimulates bone formation by regulating the expression of key enzymes like PHOSPHO1, which is crucial for bone mineralization.
- In experiments with cultured osteoblasts, PHOSPHO1 expression was significantly inhibited after a few cycles of iPTH, while other enzymes like Alpl required more cycles for similar effects.
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Bone marrow-derived mesenchymal stem cells (BMSCs) are commonly used seed cells, and BMSC-derived primed cartilage templates have been shown to achieve bone regeneration in bone tissue engineering. Aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor involved in various cellular processes such as osteogenesis and immune regulation. This study investigated the effects of the AhR endogenous ligand 6-formyl (3,2-) carbazole (FICZ) on the behavior of BMSCs and cartilage templates as well as the possible underlying molecular mechanisms.
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