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| http://dx.doi.org/10.1016/j.ygyno.2004.09.035 | DOI Listing |
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The treatment of intravascular leiomyomatosis with different clinical manifestations: Two case reports.
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Department of Gynecology and Obstetrics, The First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China.
Rationale: Intravascular/intravenous leiomyomatosis (IVL) is a rare benign smooth muscle cell tumor with malignant biological behavior. The early diagnosis of IVL is challenging, and the range of treatment options is extensive.
Patient Concerns: Herein, we present 2 cases of IVL that present markedly different clinical presentations.
Prognostic significance of trophoblastic differentiation and β-hCG secretion in somatic malignancies of uterine corpus: A systematic review with survival analysis.
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Division of Pediatric Hematology and Oncology, Kasturba Medical College, Manipal Academy of Higher Education, Manipal, Karnataka, India.
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Breast lump as the initial presentation of metastatic uterine leiomyosarcoma.
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Ilker Sengul, Division of Endocrine Surgery, Department of General Surgery, Giresun University Faculty of Medicine, Giresun, Turkey,
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Department of Pathology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA. Electronic address:
Uterine leiomyosarcoma (uLMS) is a rare and deadly gynecologic malignancy. uLMS is histologically heterogeneous and presents with a wide spectrum of tumor differentiation, with a broad range of genomic DNA instability, which can make the diagnosis and prognosis of uLMS challenging. Methylation has emerged as a useful molecular tool in tumor classification and diagnosis in certain neoplasms.
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Department of Surgery, Yale School of Medicine, New Haven, CT 06520, USA.
Uterine leiomyomas (ULM) and uterine leiomyosarcomas (ULMS) represent smooth muscle tumors with similar initial presentations but drastically different outcomes. This literature review analyzes the similarities and differences in their epigenetic profiles to identify diagnostic biomarkers and potential therapeutic targets that could improve clinical management. Both tumor types exhibit mostly distinct epigenetic signatures while sharing key pathway dysregulations.
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