Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1051/medsci/2005213237 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Hair cell identity establishes labeled lines of directional mechanosensation.
PLoS Biol
July 2018
Unit of Sensory Biology & Organogenesis, Helmholtz Zentrum München, Munich, Germany.
Directional mechanoreception by hair cells is transmitted to the brain via afferent neurons to enable postural control and rheotaxis. Neuronal tuning to individual directions of mechanical flow occurs when each peripheral axon selectively synapses with multiple hair cells of identical planar polarization. How such mechanosensory labeled lines are established and maintained remains unsolved.
View Article and Find Full Text PDFDirectional selectivity of afferent neurons in zebrafish neuromasts is regulated by Emx2 in presynaptic hair cells.
Elife
April 2018
Section on Sensory Cell Development and Function, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, United States.
The orientation of hair bundles on top of sensory hair cells (HCs) in neuromasts of the lateral line system allows fish to detect direction of water flow. Each neuromast shows hair bundles arranged in two opposing directions and each afferent neuron innervates only HCs of the same orientation. Previously, we showed that this opposition is established by expression of Emx2 in half of the HCs, where it mediates hair bundle reversal (
A forward genetic screen with a thalamocortical axon reporter mouse yields novel neurodevelopment mutants and a distinct emx2 mutant phenotype.
Neural Dev
January 2011
Howard Hughes Medical Institute, Department of Neurology, Beth Israel Deaconess Medical Center, Boston, MA, USA.
Background: The dorsal thalamus acts as a gateway and modulator for information going to and from the cerebral cortex. This activity requires the formation of reciprocal topographic axon connections between thalamus and cortex. The axons grow along a complex multistep pathway, making sharp turns, crossing expression boundaries, and encountering intermediate targets.
View Article and Find Full Text PDFMolecular regulation of the developing commissural plate.
J Comp Neurol
September 2010
Queensland Brain Institute, University of Queensland, Brisbane, QLD 4072, Australia.
Coordinated transfer of information between the brain hemispheres is essential for function and occurs via three axonal commissures in the telencephalon: the corpus callosum (CC), hippocampal commissure (HC), and anterior commissure (AC). Commissural malformations occur in over 50 human congenital syndromes causing mild to severe cognitive impairment. Disruption of multiple commissures in some syndromes suggests that common mechanisms may underpin their development.
View Article and Find Full Text PDFEmx3 is required for the differentiation of dorsal telencephalic neurons.
Dev Dyn
August 2009
Institute of Developmental Biology, University of Freiburg, Freiburg, Germany.
emx3 is first expressed in prospective telencephalic cells at the anterior border of the zebrafish neural plate. Knockdown of Emx3 function by morpholino reduces the expression of markers specific to dorsal telencephalon, and impairs axon tract formation. Rescue of both early and late markers requires low-level expression of emx3 at the one- or two-somite stage.
View Article and Find Full Text PDF