Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
A novel C-D...N interaction promotes an equilibrium isotope effect that causes a large chemical shift difference (43 ppb, 22 degrees C) for the diastereotopic methyl protons in the (N-CH2D)-(-)-isosparteinium cation. The observed chemical shift difference is in surprising agreement with a prediction of 44 ppb based upon an ab initio protocol. These calculations are also shown to reproduce the experimental shift difference in Anet's alpha-deutero-1,2-dimethylpiperidine (theory, 17 ppb; experiment, 14 ppb). The isosparteine-derived system described herein may provide an improved method for assigning the configuration and enantiomeric purity of stereogenic methyl groups (R-CHDT) by tritium NMR spectroscopy.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1021/ja034242l | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Transformations in plasma metabolic profiles of patients with major depression disorder during treatment.
Metab Brain Dis
September 2025
Department of Pharmacy, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, No. 1277, Jiefang Avenue, Wuhan, Hubei, 430022, China.
Major depression disorder (MDD) is a mental condition that significantly threatens both physical and psychological health. This study aimed to discern variances in plasma metabolic profiles between MDD sufferers and healthy counterparts. Additionally, we tracked the hospitalization journey of MDD patients to investigate the normalization of metabolic irregularities through conventional treatment in the form of self-control.
View Article and Find Full Text PDFIntermolecular Lithium η-Alkene and κ-Alkane Complexes: Synthesis, Bonding, and Facile Interconversion.
J Am Chem Soc
September 2025
Institute of Organometallic Chemistry, Russian Academy of Sciences, Tropinina 49, GSP-445, Nizhny Novgorod 603950, Russia.
In this work, an approach enabling the synthesis of η-alkene lithium complexes (Carb)Li(η-L) (L = 1-octene, cyclohexene) is elaborated. For 1,5-hexadiene, the same approach results in a binuclear μ-η:η-diene complex. The QTAIM parameters reveal the electrostatic nature of the Li-alkene interaction.
View Article and Find Full Text PDFMetagenomic research on the structural difference of plaque microbiome from different caries stages and the construction of a caries diagnostic model.
mSystems
September 2025
Department of Stomatology, Qingdao Women and Children's Hospital Affiliated to Qingdao University, Qingdao, Shandong, China.
Development of dental caries is a dynamic process; yet, there is limited knowledge on microbial differences at various stages of caries at higher resolution. To investigate the shifting microbiome profiles across different caries stages, 30 children were enrolled in this study, including 15 caries-active patients and 15 caries-free individuals. Plaque samples were collected from the buccal surface of caries-free subjects, defined as confident health (CH; = 15).
View Article and Find Full Text PDFPET Glycolysis by Modulating the Crystal Facets of PW@UiO-67: Understanding the Activation of Dual Substrates.
Small
September 2025
State Key Laboratory of Chemical Resource Engineering, Beijing University of Chemical Technology, Beijing, 100029, P. R. China.
Polyethylene terephthalate (PET) glycolysis presents an effective solution to address plastic pollution while promoting the utilization of renewable resources. It is highly important to gain in-depth insights into the identification of the well-defined active sites and the structure-activity relationships in PET glycolysis. Herein, PW@UiO-67 with different exposed crystal facets, i.
View Article and Find Full Text PDFAn update on practice patterns of North American and European veterinary neurology and surgery specialists for surgical management of acute canine thoracolumbar intervertebral disc extrusion.
J Small Anim Pract
September 2025
Small Animal Clinic, University of Veterinary Medicine Hannover, Hannover, Germany.
Objectives: A thorough understanding of common practice patterns in a particular specialty can help identify and design new interventions to improve care delivery and access to care. The goals of this study were to document current practice patterns among veterinary "neurologists" and small animal "surgeons" in the surgical management of acute canine thoracolumbar intervertebral disc extrusion, to compare approaches between these two groups and to discuss current results compared to those published in 2016.
Materials And Methods: A web-based survey was distributed in October 2024 to collect responses from board-certified and regionally recognised neurology and surgery specialists in North America and Europe.