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Objective: To study the influence of three kinds of retainers on the abutment movement of removable partial dentures (RPDs) for restoring the dentition with unilateral distal-extended tooth missing.
Methods: The combined clasp, the extension clasp and the telescopic crown were designed to retain RPDs. When food chip was masticated between dentitions, the displacement of abutments was measured by a high-sensitive-laser-transferring-detector, and then the data was statistically analyzed.
Results: All of abutments showed the inclination, torsion and vertical translocation. Of them, abutments with telescopic crowns had the lowest horizontal torsion (P < 0.01) and the highest vertical translocation (P < 0.01).
Conclusions: Compared with the combined clasp and the extension clasp, the telescopic crowns enable abutments to bear the load more axial and the stress to be distributed more even, so the design of the telescopic crown may be considered more favourable for the health of abutments.
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J Prosthodont
August 2025
Department of Prosthodontics, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine; College of Stomatology, Shanghai Jiao Tong University; National Cancer for Stomatology; National Clinical Research Center for Oral Diseases; Shanghai Key Laboratory of Stomatology; Shang
Purpose: This in vitro study aims to compare the effects of electrolytic polishing (EP), plasma electrolytic polishing (PP), dry electropolishing (DP), and their combination on the surface characteristics, corrosion resistance, and material reduction of selective laser melting (SLM) printed dental cobalt-chromium (Co-Cr) alloy.
Materials And Methods: Standard samples and removable partial denture (RPD) frameworks were SLM-printed and then polished using the following methods: mechanical polishing (MP), EP, PP, DP, PDP (PP + DP), DPP (DP + PP), and PDPP (PP + DP + PP). Surface characteristics were analyzed using optical profilometry, scanning electron microscopy (SEM), and x-ray photoelectron spectroscopy (XPS).
Cancer Res Commun
September 2025
Department of Gastrointestinal Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas.
Purpose: The BRAF inhibitor encorafenib (Enco) plus the anti-EGFR antibody cetuximab (Cetux) improved overall survival, objective response rate, and progression-free survival in previously treated BRAFV600E-mutant metastatic colorectal cancer in BEACON, a phase III randomized trial, leading to regulatory approval for this indication. To support rapid, plasma-based testing for BRAFV600E identification, clinical validity of a ctDNA-based assay, FoundationOneLiquid CDx (F1LCDx), was assessed against the reference tumor-based clinical trial assay (CTA) in liquid biopsy-evaluable samples from BEACON and commercially obtained tissue-matched plasma samples.
Patients And Methods: Pretreatment tissue samples were collected in BEACON to confirm BRAF mutational status using the central single gene PCR assay.
medRxiv
July 2025
Hillman Cancer Center, UPMC, Pittsburgh, PA, USA.
Background: Cancers that do not respond to immunotherapy typically harbor a non-T cell-inflamed tumor microenvironment (TME), characterized by the absence of type I/II interferon (IFN) signaling and CD8 T cell infiltration. We previously reported somatic mutations were enriched in non-T cell-inflamed tumors across tumor types. Consistent with this, mutant IDH1 (mIDH1) has been demonstrated to drive immune exclusion through metabolic reprogramming of the TME, and IDH inhibition enhanced anti-tumor immunity in preclinical models.
View Article and Find Full Text PDFCancer
August 2025
Hillman Cancer Center, University of Pittsburgh Medical Center, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Background: New treatment options are needed for patients with metastatic anti-programmed cell death 1 (PD-1)-resistant melanoma. The final analysis of a phase 1b study evaluating the Toll-like receptor 9 agonist vidutolimod is reported here.
Methods: This two-part, open-label, multicenter, phase 1b study in adults with metastatic/unresectable anti-PD-1-resistant melanoma evaluated the safety and clinical activity of intratumoral vidutolimod plus systemic pembrolizumab (part 1) or vidutolimod alone (part 2).
Nat Cancer
July 2025
The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
The abscopal effects of radiation may sensitize immunologically cold tumors to immune checkpoint inhibition. We investigated the immunostimulatory effects of radiotherapy leveraging multiomic analyses of serial tissue and blood biospecimens (n = 293) from a phase 2 clinical trial of stereotactic body radiation therapy (SBRT) followed by pembrolizumab in metastatic non-small cell lung cancer ( NCT02492568 ). Participants with immunologically cold tumors (low tumor mutation burden, null programmed death ligand 1 expression or Wnt pathway mutations) had significantly longer progression-free survival in the SBRT arm.
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