Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
In a previous paper, we presented a practical in vivo micronucleus (MN) test that used rat skin as the target organ. To evaluate the test, as well as to determine the reproducibility and applicability of the method to mice, we used it to test the effect of five skin carcinogens (N-ethyl-N'-nitro-N-nitrosoguanidine (ENNG), N-methyl-N'-nitro-N-nitrosoguanidine (MNNG), 4-nitroquinoline 1-oxide (4NQO), 7,12-dimethylbenz[a]anthracene (DMBA), and benzo[a]pyrene (B[a]P)) on rat and mouse skin. All five compounds significantly and dose-dependently increased the MN frequencies in the basal cells of the chemical-treated skin. These results indicated the reproducibility of the test results and also the applicability of the test to mice as well as rats.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/s1383-5718(01)00292-3 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
A Comprehensive Toxicological Safety Evaluation of .
Int J Toxicol
August 2025
Toxi-Coop Zrt, Budapest, Hungary.
CLB101 (CLB101) is an obligate, anaerobic bacteria that was isolated from the stool of a healthy infant. Due to its ability to produce butyrate and its potential promotion of microbiome health through multiple homeostatic interactions there is interest in its consumption by humans. No toxicity data are publicly available for any strain of .
View Article and Find Full Text PDFtoxicological evaluation of 6'-Sialyllactose sodium salt produced by a novel method.
Toxicol Rep
December 2025
GeneChem Inc., A-201, 187 Techno 2-ro, Yuseong-gu, Daejeon 34025, Republic of Korea.
6'-Sialyllactose (6'-SL) sodium salt is the sodium salt of a naturally occurring trisaccharide found in dairy products and human milk. 6'-SL sodium salt formulations produced by different methods have been the subject of other safety studies and are approved for use in food in the United States and other countries. Because the manufacturing process can influence the toxicological profile of a substance, studies were undertaken to assess the safety of 6'-SL sodium salt produced by a novel manufacturing process.
View Article and Find Full Text PDFEnhanced Anticancer Activity of Atractylodin-Loaded Poly(lactic-co-glycolic Acid) Nanoparticles Against Cholangiocarcinoma.
Polymers (Basel)
August 2025
Center of Excellence in Molecular Biology and Pharmacology of Malaria and Cholangiocarcinoma, Chulabhorn International College of Medicine, Thammasat University, Pathum Thani 12120, Thailand.
Cholangiocarcinoma (CCA) is highly prevalent in the Greater Mekong sub-region, especially northeastern Thailand, where infection with the liver fluke Opisthorchis viverrini is a major etiological factor. Limited therapeutic options and the absence of reliable early diagnosis tools impede effective disease control. (Thunb.
View Article and Find Full Text PDFPhytochemical Profile, Toxicological Screening, Antitumor Activity, and Immunomodulatory Response of Saline Extract from L. Leaves.
Molecules
July 2025
Departamento de Bioquímica, Universidade Federal de Pernambuco, Recife 50670-901, Pernambuco, Brazil.
L. is traditionally used to treat tumors and has demonstrated anticancer effects. This study evaluated the phytochemical composition, toxicity, and antitumor activity of saline extract (SE) from leaves in mice.
View Article and Find Full Text PDFIn-silico receptor interactions, phytochemical fingerprint and biological activities of Matricaria chamomilla flower extract and the main components.
Sci Rep
August 2025
Department of Biology, Faculty of Science and Art, Giresun University, Giresun, 28200, Turkey.
In this study, total phenolic and flavonoid content, quantitative phenolic analysis, in-vivo, in-vitro and in-silico biological activities of Matricaria chamomilla flower extracts collected from Bulancak (Giresun) were investigated. Phenolic content was determined by LC-MS/MS and antioxidant, antibacterial, antifungal, antigenotoxic and anti-inflammatory activities of the extract and the main components were investigated. Caffeic acid, quercetin and kaempferol were detected as major compounds in the flower extract by LC-MS/MS analysis and the detected levels were 165.
View Article and Find Full Text PDF