Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1021/jo971847p | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Exploring extreme environments in Türkiye for novel P450s through metagenomic analysis.
PLoS One
September 2025
Department of Molecular Biology and Genetics, Faculty of Science and Letters, Istanbul Technical University, Istanbul, Türkiye.
Cytochrome P450 enzymes (P450s), particularly those of microbial origin, are highly versatile biocatalysts capable of catalyzing a broad range of regio- and stere-oselective reactions. P450s derived from extremophiles are of particular interest due to their potential tolerance to high temperature, salinity, and acidity. This study aimed to identify and classify novel microbial P450 enzymes from extreme environments across Türkiye, including hydrothermal springs, hypersaline lakes, and an acid-mine drainage site.
View Article and Find Full Text PDFStereoselective Synthesis of α-Aminophosphonates and Their Derivatives via Asymmetric α-Azidation of the CAMDOL-Derived Phosphonates.
Org Lett
September 2025
State Key Laboratory of Chemistry for NBC Hazards Protection, Beijing 102205, China.
Optically active α-aminophosphonic acids are unique analogues of α-amino acids, and numerous synthetic methods have been developed. Herein, we present a highly diastereoselective α-azidation approach to the CAMDOL-derived phosphonates, enabling ready access to 27 diverse α-azidophosphonates with defined chirality in up to 85% yield and more than 99:1 dr. Late-stage transformations through the Staudinger reaction or click reaction efficiently delivered the related pharmacological α-aminophosphonic acids or the unique α-triazolylphosphonate derivative, respectively.
View Article and Find Full Text PDFSynthesis of Highly Substituted Alkenes from Terminal Alkynes.
J Am Chem Soc
August 2025
Department of Chemistry, University of Washington, Seattle, Washington 98195, United States.
Alkenes make up an important class of compounds prevalent in biologically active molecules and synthetic intermediates. Their significance has driven the development of robust synthetic methods that allow the efficient and selective production of mono- and disubstituted alkenes. However, the selective synthesis of more highly substituted alkenes from readily accessible starting materials remains a significant synthetic challenge.
View Article and Find Full Text PDFBiosynthesis Strategies and Application Progress of Mandelic Acid Based on Biomechanical Properties.
Microorganisms
July 2025
School of Life Science, Beijing Institute of Technology, Beijing 100081, China.
Mandelic acid (MA), as an important chiral aromatic hydroxy acid, is widely used in medicine, the chemical industry, and agriculture. With the continuous growth of market demand, traditional chemical synthesis methods are increasingly inadequate to meet the requirements of green and sustainable development due to issues such as complex processes, poor stereoselectivity, numerous byproducts, and serious environmental pollution. MA synthesis strategies based on biocatalytic technology have become a research hotspot due to their high efficiency, environmental friendliness, and excellent stereoselectivity.
View Article and Find Full Text PDFPhotoredox/Nickel Dual Catalysis for Regio- and Stereoselective Reductive Coupling of Alkynes with Vinyl Phosphonates.
J Org Chem
August 2025
Department of Chemistry, SRM University-AP, Amaravati, Andhra Pradesh 522240, India.
An efficient nickel-photoredox dual-catalyzed intermolecular reductive coupling reaction of alkynes with vinyl phosphonates is described. The reaction is highly regio- and stereoselective, affording the homoallylic phosphonates in good to high yields. The present protocol is also successfully applied to other activated alkenes such as enones, acrylates, and vinyl sulfone.
View Article and Find Full Text PDF