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http://dx.doi.org/10.1002/1521-3773(20011001)40:19<3593::aid-anie3593>3.0.co;2-u | DOI Listing |
Int J Mol Sci
April 2023
Department of Pharmaceutical Chemistry and Biomaterials, Faculty of Pharmacy, Medical University of Warsaw, Banacha 1 Str., 02-097 Warsaw, Poland.
The aim of this study was to develop an innovative, dual-stimuli-responsive smart hydrogel local drug delivery system (LDDS), potentially useful as an injectable simultaneous chemotherapy and magnetic hyperthermia (MHT) antitumor treatment device. The hydrogels were based on a biocompatible and biodegradable poly(-caprolactone---lactide)--poly(ethylene glycol)--poly(-caprolactone---lactide) (PCLA-PEG-PCLA, PCLA) triblock copolymer, synthesized via ring-opening polymerization (ROP) in the presence of a zirconium(IV) acetylacetonate (Zr(acac)) catalyst. The PCLA copolymers were successfully synthesized and characterized using NMR and GPC techniques.
View Article and Find Full Text PDFEnzyme Microb Technol
October 2021
School of Life Science and Engineering, Lanzhou University of Technology, Lanzhou, 730050, China.
A novel magnetic thermosensitive polymer composite carrier with target spacing was developed. In this strategy, thermosensitive polymer grafted on magnetic FeO for enhancing immobilized penicillin G acylase (PGA) performance and introduce immobilized target spacing into magnetic carriers for the first time. FeO nanoparticles were synthesized by a reverse microemulsion method.
View Article and Find Full Text PDFBiomed Res Int
February 2021
Department of Urology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, China.
Nanoscopic therapeutic systems that incorporate therapeutic agents, molecular targeting, and imaging capabilities have gained momentum and exhibited significant therapeutic potential. In this study, multifunctional polymeric nanoparticles with controlled drug delivery, cancer-targeted capability, and efficient magnetic resonance imaging (MRI) contrast characteristics were formulated and applied in the treatment of castration-resistant prostate cancer (CRPC). The "core-shell" targeted nanoparticles (NPs) were synthesized by the self-assembly of a prefunctionalized amphiphilic triblock copolymer composed of poly(lactic-co-glycolic-acid) (PLGA), polyethylene glycol (PEG), and the Wy5a aptamer (Apt), which have been screened for targeting the CRPC cell line PC-3 by cell-SELEX technique as described in our previous study.
View Article and Find Full Text PDFMacromol Rapid Commun
January 2019
Key Centre for Polymers and Colloids, School of Chemistry and University of Sydney Nano Institute, The University of Sydney, NSW, 2006, Australia.
RAFT-mediated free-radical emulsion polymerization is successfully used to synthesize polystyrene nanofibers using triblock amphiphilic macro-RAFT copolymers as stabilizers. The polymerization is under RAFT control, producing various morphologies from spherical particles, nanofibers, nanoplatelets, and polymer vesicles. Optimum conditions are established for the synthesis of predominantly negatively charged polymer nanofibers.
View Article and Find Full Text PDFJ Pharm Sci
December 2018
Department of Physics, Sharif University of Technology, P.O. Box 11365-9567, Tehran, Iran. Electronic address:
Three magneto-plasmonic nanohybrids were synthesized using Au- and Ag-coated FeO nanoparticles (NPs)-modified dual pH- and temperature-responsive triblock copolymer of poly (butyl methacrylate-co-acrylamide-co-methacrylic acid) to serve as drug carriers with potential of using in both photothermal and controlled/targeted chemotherapies. The internal superparamagnetic core gives the carriers targeted-delivery characteristics, and surface plasmon resonance-based noble metallic Au/Ag shells give them on-demand photothermal and photo-triggering release properties. To investigate the effect of coating method on the targeting property of synthesized carriers, Au NPs were attached to the magnetic core by 2 different direct/indirect procedures and the properties of the synthesized carriers including swelling ratio and thermal and optical sensitivity and switching were comprehensively investigated in 2 different buffer solutions with pH 5.
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