A near-infrared aggregation-induced emission photosensitizer with mitochondria specificity enhances radiotherapy for cancer stem cells ablation.

Multifunctional fluorescent molecules with organelle-targeting capabilities and high phototherapeutic efficacy have been regarded as promising materials for real-time tumor diagnosis and non-invasive treatment in the clinic. In this study, we developed a near-infrared (NIR) emissive photosensitizer, DACNPy+, which exhibits mitochondrial targeting ability, laser-triggered type I and type II reactive oxygen species (ROS) generation, and aggregation-induced emission (AIE) properties. After being encapsulated by platelet membranes and liposomal membranes, DACNPy+ was formulated into biomimetic nanoparticles termed DFL, which demonstrated remarkable tumor-targeting capabilities and long-term tumor tracking.

Transition Metal Atom-Cluster Synergistic Modification with Tuned d-band Center Imparts Longevous Potassium Metal Anodes.

The tailored nucleation and growth of potassium metal over a current collector is essential to realize longevous potassium metal anodes. The commercial current collector lacks sufficient nucleation sites and fails to guide uniform deposition, underscoring the request for interfacial modulation maneuvers. Herein, we develop transition metal atom-cluster moiety decorated N-doped hollow carbon nanosphere to modify the Al current collector.

Dictating Zn Transport Kinetics via Versatile Ionic Covalent Organic Framework for Robust Zn Metal Anodes.

Covalent organic frameworks (COFs) offer a promising platform in regulating ion transport and stabilizing electrode-electrolyte interfaces owing to their tailorable porosity and versatile moiety. Compared to widely employed neutral COFs, ionic COFs (iCOFs) harness strong electrostatic interactions to selectively interact with target ions, thereby helping accelerate ion-pair dissociation. Furthermore, the charged backbones of iCOFs induce interlayer electrostatic repulsion, driving spontaneous exfoliation and hence promoting ion transport kinetics.

Analysis of Residual Compressive Strength in 3D Four-Directional Braided Composites After Hygrothermal Aging.

This study investigates the effect of hygrothermal environments on the compressive properties of three-dimensional four-directional braided composites through experiments and finite element simulations, revealing the degradation behavior under various hygrothermal conditions. The results indicate that the moisture absorption behavior of the material conforms to Fick's law. The longer the hygrothermal aging duration and the higher the temperature, the more significant the reduction in compressive performance, as evidenced by the continuous decline in ultimate stress.

Advances in the Biological Functions and Mechanisms of miRNAs in the Development of Osteosarcoma.

Osteosarcoma is one of the most common primary malignant bone tumors, mainly occurring in children and adolescents, and is characterized by high morbidity and poor prognosis. MicroRNAs, a class of noncoding RNAs consisting of 19 to 25 nucleotides, are involved in cell proliferation, invasion, metastasis, and apoptosis to regulate the development and progression of osteosarcoma. Studies have found that microRNAs are closely related to the diagnosis, treatment, and prognosis of osteosarcoma patients and have an important role in improving drug resistance in osteosarcoma.