Publications by authors named "Zhuoying Zeng"
Objectives: To analyze the global stroke burden attributable to household air pollution (HAP) using Global Burden of Disease (GBD) 2021 data, examine its spatiotemporal patterns from 1990-2021, and project future trends through 2040.
Study Design: Retrospective analysis using GBD data with future projections.
Methods: Analysis of age-standardized rates, deaths, disability-adjusted life years (DALYs), years lived with disability (YLDs), and years of life lost (YLLs) due to HAP-related stroke across 204 countries.
Mulberry leaves contain polysaccharides, phenols, alkaloids, and other active ingredients which have medicinal and edible value. In this study, fermented mulberry leaf powder was prepared by solid-state fermentation using JC30. The effects of the fermentation on the phytochemical, flavor characteristics, phenolics, and antioxidant activity of mulberry leaves were studied.
View Article and Find Full Text PDFObjectives: The objective of this study was to develop and validate an automated solid-phase extraction (SPE) coupled with ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) method for the detection of sodium pentachlorophenolate (PCP-Na) residues on cutting boards. Given the potential hazards and environmental persistence of PCP-Na, a sensitive and reliable method is crucial for monitoring its residues in food contact materials to ensure consumer safety.
Methods: Wood shavings from cutting boards were extracted using 10% methanol in water, followed by purification using an automated SPE system.
Osteoporosis is a systemic skeletal disease characterized by low bone density and microarchitectural deterioration, resulting in increased fracture risk. With an aging population, osteoporosis imposes a heavy burden worldwide. Current pharmacotherapies such as bisphosphonates can reduce fracture risk but have limitations.
View Article and Find Full Text PDFResearch integrity in the era of artificial intelligence: Challenges and responses.
Medicine (Baltimore)
July 2024
Article Synopsis
- AI helps scientists work faster and more accurately, but it also leads to cheating, like making up data or copying text.
- To fix these problems, the study suggests making strict rules for using AI in research and providing training about how to use it ethically.
- Working together internationally can help researchers share good practices and ensure that everyone follows the same rules to keep science trustworthy.
Article Synopsis
- Cell membrane surface tension is an important factor that affects how cells behave and can influence their future development.
- New techniques, like micropipette aspiration and fluorescent probes, help scientists measure this surface tension accurately.
- Changes in cell membrane surface tension can impact processes like cell movement and growth, which can be important for understanding diseases and developing medical treatments.
Article Synopsis
- The article investigates the ethical concerns associated with artificial intelligence (AI), discussing its benefits as well as negative implications on society.
- It focuses on the medical field, but also addresses potential ethical and legal challenges in other areas like autonomous driving, finance, and security.
- Recommendations are provided for policymakers and technology companies to enhance regulations, improve public understanding of AI, and leverage its advantages for a more equitable and sustainable society.
Poly(ADP-ribose) glycohydrolase (PARG) as a main enzyme hydrolyzing poly(ADP-ribose) in eukaryotes, and its silencing can inhibit benzo(a)pyrene (BaP)-induced carcinogenesis. A thorough understanding of the mechanism of PARG silenced inhibition of BaP-induced carcinogenesis provides a new therapeutic target for the prevention and treatment of environmental hazard induced lung cancer. We found that the expression of several subtypes of the histone H2B was downregulated in BaP-induced carcinogenesis via PARG silencing as determined by label-free proteomics and confirmed by previous cell line- and mouse model-based studies.
View Article and Find Full Text PDFBenzo(a)pyrene (BaP) is a polycyclic aromatic hydrocarbon that specifically causes cancer and is widely distributed in the environment. Poly (ADP-ribosylation), as a key post-translational modification in BaP-induced carcinogenesis, is mainly catalyzed by poly (ADP-ribose) glycohydrolase (PARG) in eukaryotic organisms. Previously, it is found that PARG silencing can counteract BaP-induced carcinogenesis , but the mechanism remained unclear.
View Article and Find Full Text PDFPoly (ADP-ribosylation) is a key post-translational modification (PTM), and poly (ADP-ribose) glycohydrolase (PARG) is the main enzyme that hydrolyzes poly (ADP-ribose) in eukaryotic organisms. Our previous findings suggested that knockdown of PARG attenuates benzo(a)pyrene (BaP) carcinogenesis. However, the mechanisms underlying PARG-mediated protective effects remain limited.
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