Publications by authors named "Zhuoran Hou"

Heritability is a fundamental parameter of diseases and other traits, quantifying the contribution of genetics to that trait. Kinship matrices, also known as Genetic Relatedness Matrices or "GRMs", are required for heritability estimation with variance components models. However, the most common "standard" kinship estimator employed by GCTA and other approaches, can be severely biased in structured populations.

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  • The study investigates the link between retinal degeneration and neurodegenerative diseases, highlighting the complex interactions within the nervous system.
  • RNA-seq analysis of retinal degeneration in RP mice and PD mice identifies common genes, specifically Cnr1 and Septin14, that may play a role in both conditions.
  • The findings suggest that these genes could be potential targets for treatment, aiming to improve understanding and strategies for managing both retinal and neurodegenerative diseases.
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Staining frozen sections is often required to distinguish cell types for spatial transcriptomic studies of the brain. The impact of the staining methods on the RNA integrity of the cells becomes one of the limitations of spatial transcriptome technology with microdissection. However, there is a lack of systematic comparisons of different staining modalities for the pretreatment of frozen sections of brain tissue as well as their effects on transcriptome sequencing results.

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  • Several methods exist for estimating causal effects, but most struggle with complex data types like images.
  • The proposed Causal Multi-task Deep Ensemble (CMDE) framework effectively learns both shared and unique information from different groups within a study population.
  • CMDE demonstrates superior performance over current state-of-the-art methods by efficiently managing high-dimensional data and providing reliable estimates of causal effects across various datasets and tasks.*
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The escalating environmental concerns and energy crisis caused by internal combustion engines (ICE) have become unacceptable under environmental regulations and the energy crisis. As a promising alternative solution, multi-power source electric vehicles (MPS-EVs) integrate various clean energy systems to enhance the powertrain efficiency. The energy management strategy (EMS) is plays a pivotal role for MPS-EVs to maximize efficiency, fuel economy, and range.

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Severe weather conditions pose a significant challenge for computer vision algorithms in autonomous driving applications, particularly regarding robustness. Image rain-removal algorithms have emerged as a potential solution by leveraging the power of neural networks to restore rain-free backgrounds in images. However, existing research overlooks the vulnerability concerns in neural networks, which exposes a potential threat to the intelligent perception of autonomous vehicles in rainy conditions.

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Under the trend of vehicle intelligentization, many electrical control functions and control methods have been proposed to improve vehicle comfort and safety, among which the Adaptive Cruise Control (ACC) system is a typical example. However, the tracking performance, comfort and control robustness of the ACC system need more attention under uncertain environments and changing motion states. Therefore, this paper proposes a hierarchical control strategy, including a dynamic normal wheel load observer, a Fuzzy Model Predictive Controller and an integral-separate PID executive layer controller.

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  • A novel 3D composite electrode material was created using nanoscale NiMnLDH-Co(OH) grown on nickel foam through hydrothermal electrodeposition, enhancing electrochemical performance.
  • The unique structure provided numerous reactive sites and effective charge transfer, resulting in a specific capacitance of 1870 F/g and excellent stability over 3000 cycles.
  • Additionally, the NiMnLDH-Co(OH)//AC supercapacitor exhibited remarkable energy and power metrics while maintaining high cycle stability, showcasing its potential for advanced energy storage applications.
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Common genetic association models for structured populations, including principal component analysis (PCA) and linear mixed-effects models (LMMs), model the correlation structure between individuals using population kinship matrices, also known as genetic relatedness matrices. However, the most common kinship estimators can have severe biases that were only recently determined. Here we characterize the effect of these kinship biases on genetic association.

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The mechanical coupling of multiple powertrain components makes the energy management of 4-wheel-drive (4WD) plug-in fuel cell electric vehicles (PFCEVs) relatively complex. Optimizing energy management strategies (EMSs) for this complex system is essential, aiming at improving the vehicle economy and the adaptability of operating conditions. Accordingly, a novel adaptive equivalent consumption minimization strategy (A-ECMS) based on the dragonfly algorithm (DA) is proposed to achieve coordinated control of the powertrain components, front and rear motors, as well as the fuel cell system and the battery.

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An energy management strategy is a key technology used to exploit the energy-saving potential of a plug-in hybrid electric vehicle. This paper proposes the environmental perceiver-based equivalent consumption minimization strategy (EP-ECMS) for parallel plug-in hybrid vehicles. In this method, the traffic characteristic information obtained from the intelligent traffic system is used to guide the adjustment of the equivalence factor, improving the environmental adaptiveness of the equivalent consumption minimization strategy (ECMS).

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Energy management strategies are vitally important to give full play to the energy-saving of the four-wheel drive electric vehicle (4WD EV). The cooperative output of multi-power components is involved in the process of driving and braking energy recovery of 4WD EV. This paper proposes a novel energy management strategy of dual equivalent consumption minimization strategy (D-ECMS) to improve the economy of the vehicle.

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A battery's charging data include the timing information with respect to the charge. However, the existing State of Health (SOH) prediction methods rarely consider this information. This paper proposes a dilated convolution-based SOH prediction model to verify the influence of charging timing information on SOH prediction results.

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Existing data-driven technology for prediction of state of health (SOH) has insufficient feature extraction capability and limited application scope. To deal with this challenge, this paper proposes a battery SOH prediction model based on multi-feature fusion. The model is based on a convolutional neural network (CNN) and a long short-term memory network (LSTM).

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Energy management strategies are vitally important to give full play to energy-saving four-wheel-drive plug-in hybrid electric vehicles (4WD PHEV). This paper proposes a novel dual-adaptive equivalent consumption minimization strategy (DA-ECMS) for the complex multi-energy system in the 4WD PHEV. In this strategy, management of the multi-energy system is optimized by introducing the categories of future driving conditions to adjust the equivalent factors and improving the adaptability and economy of driving conditions.

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  • Vehicle speed prediction is crucial for enhancing energy management strategies by anticipating a vehicle's future driving status.
  • The proposed VSNet architecture combines CNN and LSTM to process a "fake image" of vehicle signals from the past 15 seconds to predict speed for the next 5 seconds.
  • Its performance metrics indicate high accuracy, with RMSE values between 0.519 and 2.681 and R² values between 0.997 and 0.929, leading to a 4.74% increase in fuel consumption compared to traditional methods, while being more efficient than less accurate speed prediction techniques.
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With the development of technology, speed prediction has become an important part of intelligent vehicle control strategies. However, the time-varying and nonlinear nature of vehicle speed increases the complexity and difficulty of prediction. Therefore, a CNN-based neural network architecture with two channel input (DICNN) is proposed in this paper.

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Cognitive decline is a central feature in the aging process. Previous studies have indicated an association between depressive symptoms and cognitive decline in Caucasian populations. However, few studies have examined the effect of changes in depression on the trajectory of cognitive decline.

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P2X receptors are ligand-gated ion channels that can bind with the adenosine triphosphate (ATP) and have diverse functional roles in neuropathic pain, inflammation, special sense, and so on. In this study, 180 putative P2X genes, including 176 members in 32 animal species and 4 members in 3 species of lower plants, were identified. These genes were divided into 13 groups, including 7 groups in vertebrates and 6 groups in invertebrates and lower plants, through phylogenetic analysis.

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