A Structured Approach to Extubation in Mechanically Ventilated Rats.

Mechanical ventilation (MV) is widely used in critical care but is associated with various complications that affect both short- and long-term outcomes, including ventilator-induced lung injury, ventilator-induced diaphragm dysfunction, and ventilator-associated brain injury. These are key components of post-intensive care unit syndrome (PICS). Rodent models are vital for investigating the prolonged impacts and underlying mechanisms of MV, yet standardized post-extubation models remain limited.

Study on the mechanism of NLRP3 effect on the skeleton of de-ovalized mice.

Postmenopausal osteoporosis caused by estrogen deficiency affects millions of women worldwide. By influencing both osteoblast and osteoclast development, NOD-like receptor thermoprotein structural domain-associated protein 3 (NLRP3) is a key player in the etiology of osteoporosis (OP). The purpose of this research was to look into the mechanism of action of NLRP3 in osteoporosis caused by a lack of estrogen, highlighting that NLRP3 induces osteoblast pyroptosis and thus inflammatory responses in de-ovulated mice, thereby inhibiting osteogenic differentiation and participating in the development of osteoporosis.