Engineering TLR7/8 Agonist-Loaded and Tumor-Anchored Gold Nanosensitizers for Enhanced Radioimmunotherapy.

Immunomodulators that can amplify the in situ vaccine effect by regulating radiation-induced immunosuppression have been proven to play a pivotal role in improving the radioimmunotherapeutic efficacy of tumors. Nevertheless, they still face challenges to be addressed for effective tumor radioimmunotherapy, such as poor tumor specificity, rapid clearance from lesions, and potential side effects. Herein, a folate receptors (FRs)-targeting and protein sulfenic acid (PSA)-reactive gold nanosystem FA-dAu-CDR is rationally designed and fabricated in which the toll-like receptor 7/8 immunoagonists are loaded through amphiphilic β-cyclodextrin (β-CD).

Stimulus-activated ribonuclease targeting chimeras for tumor microenvironment activated cancer therapy.

RNA degradation using ribonuclease targeting chimeras (RiboTACs) is a promising approach for cancer therapy. However, potential off-target degradation is a serious issue. Here, a RiboTAC is designed for tumor microenvironment triggered activation.

Low-carbon energy transition multi-agent network evolutionary under carbon trading scheme.

Transitioning to low-carbon energy is key for reaching carbon neutrality and modernizing our energy systems, but it presents significant cost-related challenges for energy businesses. To foster optimal outcomes, this paper develops a game model including power generators, high-energy businesses, and consumers in the carbon trading framework. The model explores how different entities evolve their low-carbon strategies under social learning influence to optimize utility.

Promising Low-Cost Adsorbent from Waste Green Tea Leaves for Phenol Removal in Aqueous Solution.

Phenol is the most common organic pollutant in many industrial wastewaters that may pose a health risk to humans due to its widespread application as industrial ingredients and additives. In this study, waste green tea leaves (WGTLs) were modified through chemical activation/carbonization and used as an adsorbent in the presence of ultrasound (cavitation) to eliminate phenol in the aqueous solution. Different treatments, such as cavitation, adsorption, and sono-adsorption were investigated to remove the phenol.