Publications by authors named "Zhining Ou"

Current guidelines, quality indicators, and recommendations broadly recognize the importance of behavioral health care integrated into routine epilepsy visits; however, no specific guidance currently exists for how to implement this care. To address this gap, the Value-based special interest group (SIG) of the Pediatric Epilepsy Research Consortium (PERC) developed and disseminated a survey to inquire about availability and access to behavioral health care and roles of behavioral health care providers (e.g.

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TAVR is an alternative to surgical aortic valve [AoV] replacement. In adults, rates of atrioventricular block [AVB] requiring permanent pacemaker [PPM] placement in the modern era are 4-24%. Post-TAVR conduction abnormality incidence and risk factors are unknown in children and young adults.

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Background: In 2019, the Society for Cardiovascular Angiography and Interventions (SCAI) proposed an algorithm to assess cardiogenic shock (CS) severity, known as SCAI classification. In 2022, the Cardiogenic Shock Working Group (CSWG) modified the original classification using specific parameters to better define hypotension and hypoperfusion with the goal to further refine stratification.

Methods: Consecutive patients with CS who were managed at a quaternary academic medical centre from May 2015 to December 2021 were evaluated (N = 1162).

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Background: Patient-reported outcome measures (PROMs) correlate with heart failure (HF) severity among adults and are adjunct tools in clinical care. Limited data exist regarding the validity of PROMs in pediatric HF. Patient-Reported Outcome Measurement Information System (PROMIS) Pediatric Fatigue correlates with HF severity, measured by the New York University Pediatric Heart Failure Index (NYU PHFI).

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The objective of this study was to explore whether the time of day (AM vs. PM) resistance exercise is performed influences glucose and insulin concentrations, body composition, and muscular strength in adults with prediabetes. A secondary data analysis was conducted using data from the "Resist Diabetes" study, a phase II exercise intervention.

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Most epidemiological studies in pediatric heart failure (HF) use administrative database sources, defining patient cohorts by presence of a single HF ICD code. However, the ability of ICD codes to identify true HF patients is unknown in pediatrics. Here we describe the accuracy of HF ICD-10-CM code search algorithms, in identifying pediatric patients with HF from electronic data sources.

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Background: Most epidemiological studies in pediatric heart failure (HF) use administrative database sources, defining patient cohorts by presence of a single HF ICD code. However, the ability of ICD codes to identify true HF patients is unknown in pediatrics. Here we describe the accuracy of HF ICD-10-CM code search algorithms, in identifying pediatric patients with HF from electronic data sources.

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  • A study examined the relationship between post-operative ECG changes, diastolic blood pressure (DBP), and negative outcomes in patients who underwent Systemic to Pulmonary Artery shunt surgery.
  • Patients' ECGs were classified into three grades based on repolarization abnormalities, with only a small percentage showing Grade 2 abnormalities.
  • The analysis revealed no link between ECG changes or low DBP levels and adverse outcomes; however, high DBP levels above 34 mmHg appeared to increase the risk of complications in certain patients.
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  • The study aimed to understand lifetime exposure to mild traumatic brain injuries (TBIs) among U.S. military service members and Veterans, focusing on differences between male and female participants.
  • It involved analyzing data from a large longitudinal study, measuring various characteristics of mild TBIs through structured interviews.
  • Results indicated that female service members reported fewer TBIs overall and during deployment compared to males, highlighting significant sex-related differences in injury patterns prior to and during military service.
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  • This study explores the connection between white matter hyperintensities (WMHs), mild traumatic brain injury (mTBI), age, and cognitive performance in a group of combat-exposed Veterans and Service Members.
  • The research involved 1,011 participants, revealing that both groups had similar rates of WMHs; however, older individuals with mTBI showed a higher count of WMHs compared to those without.
  • Significant relationships were found linking increased WMHs with cognitive impairments in memory and processing speed, suggesting the need for further investigation on the long-term effects of WMHs in mTBI cases.
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  • Viral bronchiolitis is a common illness in kids, and while treatment is mainly supportive, some may have serious bacterial infections (cSBIs) that require antibiotics; identifying these infections can be tricky.
  • A study conducted at a children's hospital from 2012 to 2019 looked at children under 2 with bronchiolitis, finding that 4.2% had at least one cSBI, primarily bacterial pneumonia.
  • Factors increasing the risk of cSBI included needing invasive mechanical ventilation, high C-reactive protein levels, having complex chronic conditions, and being admitted to the PICU.
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We performed a secondary analysis of the Pediatric Heart Network (PHN) Marfan Trial public-use database to evaluate associations between extracardiac features and cardiac and aortic phenotypes in study participants. Aortic aneurysm phenotype was defined as aortic root Z-score ≥4.5, aortic root growth rate ≥75th percentile, aortic dissection, and aortic surgery.

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We performed a secondary analysis of the Pediatric Heart Network Marfan Trial public-use database to evaluate associations between extracardiac features and cardiac and aortic phenotypes in study participants. Aortic aneurysm phenotype was defined as aortic root Z-score ≥ 4.5, aortic root growth rate ≥ 75th percentile, aortic dissection, and aortic surgery.

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Aims: Common to adult electrophysiology studies (EPSs), intracardiac echocardiography (ICE) use in paediatric and congenital heart disease (CHD) EPS is limited. The purpose of this study was to assess the efficacy of ICE use and incidence of associated complications in paediatric and CHD EPS.

Methods And Results: This single-centre retrospective matched cohort study reviewed EPS between 2013 and 2022.

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  • The study examines the use of left atrial strain (LAS) in children with multisystem inflammatory syndrome (MIS-C) and its relation to cardiac injury and inflammation.
  • Results showed that LAS parameters were significantly lower in MIS-C patients compared to healthy controls and those with cardiac injury had even more reduced LAS metrics.
  • The findings suggest that LAS could be a reliable diagnostic tool for detecting cardiac dysfunction in MIS-C and correlates with inflammatory markers, highlighting its potential use in clinical settings.
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  • The study examined the relationship between echocardiographic and laboratory findings at admission and the severity of multisystem inflammatory syndrome in children (MIS-C) associated with COVID-19, focusing on vasoactive medication usage.
  • Out of 118 patients, 48% were given vasoactive medication, with key indicators like elevated brain natriuretic peptide, C-reactive protein, and lower left ventricular ejection fraction linked to more severe disease.
  • Results suggest that laboratory markers, particularly those indicating inflammation and heart injury, could be more effective in predicting MIS-C severity compared to strain parameters or LVEF, especially since many patients with a normal LVEF still required vasoactive support.
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  • - Behavioral dyscontrol is common among U.S. service members and veterans, especially after deployments, which can lead to conditions like PTSD and mild TBI (traumatic brain injury).
  • - The study analyzed data from over 1,800 service members and veterans to explore the relationship between the severity of PTSD symptoms, mild TBI due to deployment, and behavioral dyscontrol.
  • - Findings showed that both PTSD severity and deployment-related mild TBI are linked to behavioral dyscontrol, but the impact of mild TBI becomes less significant when PTSD symptoms are higher.
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Objective: Delayed cord clamping (DCC) is recommended for all neonates; however, adapting such practice can be slow or unsustainable, especially among preterm neonates. During DCC neonates are exposed to a cool environment, raising concerns for neonatal hypothermia. Moderate hypothermia may induce morbidities that counteract the potential benefits of DCC.

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Purpose: Achieving the minimal clinically important difference (MCID) on an outcomes instrument and reporting satisfaction with surgical outcomes are not equivalent. We hypothesized that improvement exceeding the QuickDASH and PROMIS UE CAT MCID is associated with a greater likelihood of reporting satisfaction with ligament reconstruction tendon interposition (LRTI) treatment. Our secondary hypothesis was that a subset of patients failing to meet MCID would still be satisfied.

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  • The study reviews the risks of MRI scans in pediatric patients with cardiac implantable electronic devices (CIEDs), focusing on those with epicardial or abandoned leads, where guidelines discourage routine scans.
  • A multicenter review analyzed 314 patients who underwent 389 MRIs from 2007 to 2022, assessing any adverse events or significant changes to their CIEDs post-scan.
  • Results showed only a small incidence of symptoms or CIED changes (4.9% of MRIs), suggesting that MRIs can be safely conducted for these patients without major complications.
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  • The study aimed to evaluate the effectiveness of an interdigitating reconstruction technique in reducing reintervention rates for recurrent aortic arch obstruction following surgical repair in children.
  • Data was collected from 237 patients, comparing those who underwent traditional patch augmentation with those who received the new reconstruction method, with significant findings between both groups.
  • Results showed a notable reduction in overall reintervention rates from 31% to 13% after the new technique was used, indicating its potential benefits for patients, especially those who had severe conditions like hypoplastic aortic arch or underwent the Norwood procedure.
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Background: Multisystem inflammatory syndrome in children (MIS-C) commonly involves cardiac injury with both systolic and diastolic dysfunction. Left atrial strain (LAS) detects subclinical diastolic dysfunction in adults but is infrequently used in children. We evaluated LAS in MIS-C and the associations with systemic inflammation and cardiac injury.

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Introduction: Coronary artery dilation associated with bicuspid/unicuspid aortic valves is described in adults with limited data in children. We aimed to describe the clinical course of children with bicuspid/unicuspid aortic valves and coronary dilation including coronary Z-score changes over time, association of coronary changes with aortic valve anatomy/function, and complications.

Materials And Methods: Institutional databases were searched for children ≤18 years with both bicuspid/unicuspid aortic valves and coronary dilation (1/2006-6/2021).

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Liver biopsy is essential for management in liver transplant patients with clinical features suspicious for acute cellular rejection (ACR). As more patients are transplanted for noninfectious indications, it has become increasingly common for them to receive treatment for presumed ACR before biopsy. The effect of pretreatment on the classic histologic triad of ACR's mixed portal inflammation, endothelialitis, and bile duct damage is not well described.

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