Peripheral blood mesenchymal stem cell-derived exosomes improve renal sympathetic denervation efficacy through β-catenin-mediated cardiac reprogramming.

Background: To investigate the role of self-peripheral blood mesenchymal stem cell (PBMSC)-derived exosomes (Exos) in enhancing renal sympathetic denervation (RD)-mediated heart regeneration following myocardial infarction (MI) in a porcine model.

Methods: Pigs (ejection fraction [EF] < 40% post-MI) were randomised to early sham RD or RD. At 2 weeks post-MI, autologous PBMSC-Exos were collected.

Predictive model development combining CT-FFR and SYNTAX score for major adverse cardiovascular events in complex coronary artery disease.

Patients with complex coronary artery disease (CAD) often have poor clinical outcomes. This study aimed to develop a predictive model for assessing the 1-year risk of major adverse cardiovascular events (MACE) in patients with stable complex CAD, using retrospective data collected from January 2020 to September 2023 at Guangzhou Red Cross Hospital. The goal was to enable early risk stratification and intervention to improve clinical outcomes.

Pipeline Processing via the Combination of Heat and Corona Treatments for Improving the Poly(-phenylene benzobisoxazole) Fiber Surface and Anti-Aging Performances.

Although many strategies have been reported for modified poly(-phenylene benzobisoxazole) (PBO) fiber surfaces, the absence of approaches with the potential of applications in industries limits the further applications of the fibers in a wide field. Herein, PBO fibers are modified by heat treatment combined with corona discharge treatment, which is a continuous industrialized method. Then, the surface morphology, wettability, orientation, and crystallinity of the PBO fibers are characterized in detail.