In Vivo Quantitative T and T Mapping of Human Breast Tissues Using a Custom-Built 50-mT MRI Prototype.

The renewed interest in ultra-low-field MRI (< 0.1 T), with its advantages of cost-effectiveness and portability, is expected to drive a paradigm shift from traditional MRI scanners to point-of-care imaging systems. Here, we characterized the in vivo T and T relaxation times of healthy breast tissues using quantitative MRI at 50 mT to advance the development of ultra-low-field breast MRI methodologies.

Investigation of H nuclear magnetic resonance relaxometry to screen metabolic syndrome and diabetes.

The purpose of this study was to investigate and compare the abilities of H nuclear magnetic resonance (NMR) transverse relaxation constant time (T) and longitudinal relaxation constant time (T) to screen people at the risk of diabetes and metabolic syndrome. Human blood samples were collected for NMR detection and biochemical examinations. Bivariate correlations, categorical analyses were performed to explore the relationship between NMR relaxation time and metabolic biomarkers.

A novel inversion method of 2D TD-NMR signals based on realizing unconstrained maximization of objective function.

The inversion of time-domain nuclear magnetic resonance (TD-NMR) signals is an ill-posed problem, which presents enormous challenges for the inversion algorithm. We propose a novel inversion method that converts conventional minimum objective function with non-negative constraints into an unconstrained maximization problem in the inversion of TD-NMR signals. Hence, the objective function becomes a differentiable concave function that can be solved more easily.

Optimized radio frequency coil for noninvasive magnetic resonance relaxation detection of human finger.

Noninvasive NMR measurement of human tissues, such as fingers, to achieve early detection for metabolic diseases is of important significance. The NMR relaxation measurements have a wide application prospect due to simplicity, portability, and low cost, as the static magnetic field is not required to be highly homogeneous. However, the inhomogeneous radiofrequency (RF) magnetic field (B) results in errors in the magnetic resonance relaxation times.

Sensitive Oxidation of Sorbitol-Mediated Fe by HO: A Reliable TD-NMR Method for Clinical Blood Glucose Detection.

The clinical challenge of high-accuracy blood glucose detection schemes is to overcome the detection error caused by the background interferences in different individuals. HO as the specific product of glucose oxidation can be involved in the Fe/Fe conversion and detected by the time-domain nuclear magnetic resonance (TD-NMR) method sensitively. But, in clinical applications, the oxidation of Fe is susceptible to the complex sample substrates.