The Prediction Model for Triple-Negative Breast Cancer Prognosis and Immunotherapy Efficacy Based on Single-Cell Sequencing of CD8+ T cells.

Triple-negative breast cancer (TNBC) exhibits a higher propensity for recurrence, distant metastasis, and mortality than the other subtypes of breast cancer. TNBC is primarily attributed to the lack of expression of the estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2). Single-cell sequencing results of CD8 T cells in TNBC patients were screened for differentially expressed and immune-related genes.

Cancer Recurrence Fear and Return to Work in Breast Cancer Survivors:The Mediating Effects of Health Literacy.

Purpose: This study investigates the relationships between breast cancer survivors' return to work, health literacy, and cancer recurrence fear. By employing structural equation modeling, we examine the mediating effect of health literacy on the interplay between cancer recurrence fear and the ability to return to work.

Patients And Methods: We conducted a survey involving 190 breast cancer survivors, utilizing a general information questionnaire, the Concern About Recurrence Scale, and the Health Literacy Management Scale.

Model for predicting immunotherapy based on M2 macrophage infiltration in TNBC.

Introduction: Compared to other types of breast cancer, triple-negative breast cancer (TNBC) does not effectively respond to hormone therapy and HER2 targeted therapy, showing a poor prognosis. There are currently a limited number of immunotherapeutic drugs available for TNBC, a field that requires additional development.

Methods: Co-expressing genes with M2 macrophages were analyzed based on the infiltration of M2 macrophages in TNBC and the sequencing data in The Cancer Genome Atlas (TCGA) database.