Publications by authors named "Zetao Pan"
Background: Pulmonary arterial hypertension (PAH) exhibits significant gender differences in prognosis, with male patients typically showing worse outcomes than females. These disparities may stem from differences in androgen receptor expression and activity. Clinical studies suggest that the androgen receptor plays a crucial role in the pathophysiology of PAH, influencing disease progression and treatment response.
View Article and Find Full Text PDFBackground: The co-occurrence of pulmonary hypertension (PH) in patients with pulmonary fibrosis (PF) is linked to a more unfavorable prognosis and increased mortality compared to PF cases without PH. Early intervention and comprehensive management are pivotal for improving survival outcomes. Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a protein essential in cholesterol metabolism.
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- - The study highlights that septic patients with cirrhosis have a worse prognosis than those without cirrhosis, emphasizing the need for early and accurate prognosis determination to inform treatment choices.
- - Researchers analyzed data from the MIMIC-IV database, including 1,340 septic cirrhotic patients, and found that a higher albumin-corrected anion gap (ACAG) is significantly associated with increased 28-day mortality.
- - The findings suggest that ACAG could be a useful indicator for clinicians, offering insights that may help guide treatment decisions in this high-risk patient group.
Article Synopsis
- The study investigates how certain conditions like pregnancy, transplantation, and blood transfusions trigger the production of platelet antibodies, particularly in male patients with hepatocellular carcinoma (HCC) who have no such histories.
- It reveals that the use of antitumor medications may be an independent risk factor for positive platelet antibody results, suggesting a link between cancer treatment and immune responses.
- The research indicates that monitoring platelet antibody levels in HCC patients could be crucial in preventing complications like anemia and bleeding related to their treatment, especially when they exhibit a decrease in blood cell counts.
STATs are a family of transcription factors that regulate many critical cellular processes such as proliferation, apoptosis, and differentiation. Dysregulation of STATs is frequently observed in tumors and can directly drive cancer pathogenesis. STAT1 and STAT3 are generally viewed as mediating opposite roles in cancer development, with STAT1 suppressing tumorigenesis and STAT3 promoting oncogenesis.
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