Radiotherapy-induced TACC3 confers resistance of HCC to radiotherapy and enhances IL4-dependent immunosuppression to exacerbate hepatocarcinogenesis.

Radiotherapy plays an increasingly crucial role in the treatment of hepatocellular carcinoma (HCC). However, resistance to radiotherapy remains a significant obstacle to achieving optimal treatment outcomes. Our objective is to elucidate the mechanisms underlying radiotherapy resistance.

Surgical or nonsurgical treatment for nontraumatic rotator cuff tears: Study protocol clinical trial.

Background: The optimal treatment for symptomatic, nontraumatic rotator cuff tear is unknown. The primary aim of this randomized controlled trial is to compare functional improvement after surgical and conservative treatment of nontraumatic rotator cuff tears.

Methods: This is a single-centre, randomized clinical trial with a follow-up of 12 months.