The Examination of the Effects of Exosomes Generated from Bone Marrow Mesenchymal Stem Cells on Wound Healing (In vitro Study).

Introduction: Exosomes produced by mesenchymal stem cells (MSCs) have lately garnered significant attention for their capacity to enhance wound healing. Recent studies have recognized exosomes as significant secretory products from several cell types, specifically MSCs, in regulating multiple biological processes, including wound healing. This work aims to investigate the impact of exosomes derived from the bone marrow mesenchymal stem cells (BMMSCs) of NMRI animals on keratinocyte function.

Advancing 5-hydroxymethylcytosine detection: A review of innovative nanoparticle-based electrochemical and optical biosensing approaches.

5-Hydroxymethylcytosine (5-hmC) is a hydroxylated and methylated cytosine derivative that plays a crucial role in gene expression and regulation. A noticeable reduction in 5-hmC levels has been observed during the progression of various malignant tumors, making it a key epigenetic biomarker for tumorigenesis. Although numerous analytical techniques, such as bisulfite sequencing, mass spectrometry, and chromatography, have been developed for 5-hmC detection, nanoparticle-based biosensors have attracted increasing attention because of their superior sensitivity, specificity, and efficiency.

A colorimetric probe based on peroxidase-like activity of CuAl-LDH/agarose nanocomposite hydrogel for determination of vancomycin in exhaled breath condensate.

: Vancomycin is a glycopeptide antibiotic used to treat certain bacterial infections. It works by interfering with RNA synthesis, altering cell membrane permeability, and inhibiting peptidoglycan synthesis in the cell wall. The recommended therapeutic concentration of vancomycin in plasma and serum is 5.

Development of a metal-organic framework-based nanosensor for determination of cyclosporine in plasma samples.

According to the narrow therapeutic range and multiple adverse effects of cyclosporine and the need for its therapeutic drug monitoring (TDM), in this study, an efficient zeolitic imidazolate framework-8 metal-organic framework (ZIF-8 MOF) based nanoprobe was designed for simple, rapid and high sensitive its quantification in plasma samples. After the successful synthesis of the ZIF-8 MOF, under the optimum condition, the fluorescence emission of ZIF-8 MOF, measured at an excitation wavelength of 370 nm and an emission wavelength of 417 nm, was enhanced with increasing cyclosporine concentration, due to the specific interactions between cyclosporine and the nanoprobe, including hydrogen bonding and hydrophobic effects. The nanoprobe showed a linear correlation between the analytical response and cyclosporine concentration in the concentration range of 0.

Exploring the interactions between bovine serum albumin and sodium propionate through multi-spectroscopic and molecular docking analyses.

To investigate the influence of sodium propionate (SP) on bovine serum albumin (BSA), it is important to study its thermodynamic properties, binding mode, and its impact on the conformation of it. Herein, the interactions between BSA and SP were examined using various spectroscopic methods and molecular docking analyses. The Stern-Volmer plot revealed that the SP can efficiently quench the BSA intensity through a mechanism of hybrid quenching.

Analyzing the impact of variations in land use and elevation on selected soil microbial indices and spatial distribution.

Soil biological characteristics are highly sensitive to land use changes, making them valuable indicators of soil quality. This study assesses the effects of three land use types (agriculture, rangeland, and forest) and elevation variations on soil microbial parameters and their spatial distribution in the Khaneghah region. Standard physicochemical and biological properties of the soil were measured on a total of 72 soil samples collected using systematic and random sampling techniques.

The active kappa-carrageenan coating and oxygen absorber packaging for the preservation of chilled rainbow trout fillets.

The objective of the current research was to evaluate the effects of incorporating kappa-carrageenan (KCA) coating with dill essential oil (DEO), in conjunction with oxygen absorber (OA) packaging, on the quality attributes of rainbow trout fillets throughout a 20-day period of refrigerated storage. The administered treatments included OA, KCA + OA, KCA + DEO, KCA + DEO + OA, and control. Treating the trout fillets with DEO-loaded coating and/or using OA packaging was found to be more effective in restricting the growth of total mesophilic and psychrotrophic bacteria, Enterobacteriaceae, and lactic acid bacteria.

Design and development of metal-organic framework-based nanocomposite hydrogels for quantification of deferiprone in exhaled breath condensate.

In this study, a novel fluorescence nanoprobe based on Materials of Institute Lavoisier (MIL-101) metal-organic frameworks embedding into the agarose hydrogel is fabricated using a hydrothermal technique. It uses for sensitive quantification of deferiprone in exhaled breath condensate (EBC) samples. The morphology and characterization of MIL-101/agarose nanocomposite hydrogel is studied by transmission electron microscopy, dynamic light scattering instrument, powder X-ray diffraction analysis, and Fourier transform infrared spectroscopy.

Quantification of morphine in exhaled breath condensate using a double network polymeric hybrid hydrogel functionalized with AuNPs.

Background: Morphine serves as a foundation for creating other opioid derivatives, such as hydro/oxymorphine and heroin, which possess enhanced pain-relieving properties but are also prone to addiction and abuse. In cases of morphine overdose, it not only affects multiple immune functions but can also cause severe health complications. Given these concerns and the widespread use of morphine, it is crucial to develop efficient, uncomplicated, and precise methods for accurately detecting morphine in various biological and pharmaceutical samples.

Utilizing nitrogen, sulfur, phosphorus, and chlorine co-doped carbon dots as a fluorescent probe for determination of vancomycin in exhaled breath condensate.

Vancomycin is employed to treat infections caused by gram-positive bacteria. Ensuring precise vancomycin dosages is essential to avoid the emergence of bacterial resistance. In the current study, a fluorescent nanoprobe was designed for vancomycin determination in exhaled breath condensate samples.

Development of a nanocomposite hydrogel catalyzed HO/TMB system for determination of chlordiazepoxide in exhaled breath condensate.

In this study, an enzyme mimic catalyzed HO-tetramethylbenzidine system based on UiO-66/Au NPs-PVA nanocomposite hydrogel was employed as an optical probe for chlordiazepoxide sensing. An excellent detection limit of 0.0032 μg mL with a linear range of 0.

Recent advancements in the specific determination of carcinoembryonic antigens using MOF-based immunosensors.

Carcinoembryonic antigens (CEAs) are prominent cancer biomarkers that enable the early detection of numerous cancers. For effective CEA screening, rapid, portable, efficient, and sensitive diagnosis approaches should be devised. Metal-organic frameworks (MOFs) are porous crystalline materials that have received major attention for application in high-efficiency signal probes owing to their advantages such as large specific surface area, superior chemical stability and tunability, high porosity, easy surface functional modification, and adjustable size and morphology.

Utilizing a nanocomposite aerogel grafted with FeO@GO for the extraction and determination of metoprolol in exhaled breath condensate.

This article presents a solid-phase extraction method combined with a spectrofluorometric method for the extraction/pre-concentration and determination of metoprolol (MET) in exhaled breath condensate. The extraction sorbent is an agarose aerogel nanocomposite grafted with graphene oxide (GO) FeO. The size and morphology of the nanosorbent were characterized X-ray crystallography, scanning electron microscopy, Fourier-transform infrared spectrometry, and Brunauer-Emmett-Teller analysis.

A follow-up study on "A sensitive determination of morphine in plasma using AuNPs@UiO-66/PVA hydrogel as an advanced optical scaffold".

A double solvent-assisted approach was developed for the preparation of AuNPs@UiO-66 based polyvinyl alcohol hydrogel nanocomposite and evaluated its potential as a nanoprobe for the determination of morphine. The characterization and morphology of the synthesized platform were studied and performance comparison for morphine determination was done between the synthesized scaffold and the reported one in our previous work and discussed in detail. Due to the encapsulation of AuNPs inside UiO-66 in a double solvent-assisted approach, no energy transfer was performed with UiO-66 and finally, morphine could not bind with AuNPs.

Dual-emission ratiometric fluorescent probe based on N-doped CQDs@UiO-66/PVA nanocomposite hydrogel for quantification of pethidine in human plasma.

A synchronous fluorescence spectroscopy (SFS) sensor for pethidine detection is described based on UiO-66 metal-organic frameworks (MOFs) modified with N-doped carbon quantum dots (N-CQDs) embedded in hydrogel nanocomposites. Benefitting from the inovative  design of the doping method in the carbonaceous structure, N-CQDs were successfully deposited in the pores of the UiO-66 network. Then, N-CQDs were employed as a sensitive segment toward the target molecules.

A Rayleigh light scattering technique based on β- cyclodextrin modified gold nanoparticles for phenytoin determination in exhaled breath condensate.

In the current work, a RLS technique based on β-cyclodextrin modified gold nanoparticles was validated for phenytoin determination in the exhaled breath condensate. It relies on the complexation of β-cyclodextrins using -OH groups with amine groups of phenytoin which results in an aggregation-induced Rayleigh light scattering intensity enhancement proportional to phenytoin addition. The method shows a linear relationship with phenytoin concentration in the range of 0.

A sensitive determination of morphine in plasma using AuNPs@UiO-66/PVA hydrogel as an advanced optical scaffold.

In this study, a novel turn-on fluorescence nanoprobe structure has been developed by in situ synthesis and embedding of gold nanoparticles (AuNPs) and Zr-based metal-organic frameworks (MOFs), UiO-66, in polyvinyl alcohol (PVA) hydrogel for sensitive quantification of morphine in human plasma samples. A three-dimensional network of PVA hydrogel was formed by simultaneously penetrating UiO-66 and gold ions in the hydrogel frame and reducing to AuNPs without adding any reducing agent. The morphology and characterization of this new PVA-based nanocomposite hydrogel were studied by transmission electron microscopy, dynamic light scattering instrument, energy-dispersive X-ray spectroscopy, and Fourier transform infrared spectroscopy.

Nanomaterial based PVA nanocomposite hydrogels for biomedical sensing: Advances toward designing the ideal flexible/wearable nanoprobes.

In today's world, the progress of wearable tools has gained increasing momentum. Notably, the demand for stretchable strain sensors has considerably increased owing to various potential and emerging applications like human motion monitoring, soft robotics, prosthetics, and electronic skin. Hydrogels possess excellent biocompatibility, flexibility, and stretchability that render them ideal candidates for flexible/wearable substrates.

The Effects of Lavender and Citrus aurantium on Anxiety and Agitation of the Conscious Patients in Intensive Care Units: A Parallel Randomized Placebo-Controlled Trial.

Background: Conscious patients admitted to intensive care units (ICU) suffer from anxiety and agitation for various reasons, which can affect their recovery processes.

Aims: To compare the effects of lavender and Citrus aurantium essential oils on anxiety and agitation of conscious patients admitted to ICUs.

Design: A randomized parallel placebo-controlled trial.

Synergizing Functional Nanomaterials with Aptamers Based on Electrochemical Strategies for Pesticide Detection: Current Status and Perspectives.

Owing to the high toxicity and large-scale use of pesticides, it is imperative to develop selective, sensitive, portable, and convenient sensors for rapid monitoring of pesticide. Therefore, the electrochemical detection platform offers a promising analytical approach since it is easy to operate, economical, efficient, and user-friendly. Meanwhile, with advances in functional nanomaterials and aptamer selection technologies, numerous sensitivity-enhancement techniques alongside a widespread range of smart nanomaterials have been merged to construct novel aptamer probes to use in the biosensing field.

Multiplex bioassaying of cancer proteins and biomacromolecules: Nanotechnological, structural and technical perspectives.

Since the specific proteins (carbohydrate antigens, ligands and interleukins) get raised up in body tissue or fluids in cancer cases, early detection of them will provide an effective treatment and survival rate. Sensitive and accurate determination of multiple cancer proteins can be engaged in chorus by simultaneous/multiplex detection in the biomedical fields. Bioassaying technology is one of the non-invasive, high-sensitive, and economical methods.

Psychological well-being and happiness among Middle-aged women: A cross-sectional study.

Biological, physical, and psychosocial changes that occur during the aging process can negatively impact women's mental health and happiness at midlife. In this cross-sectional study, we aimed to determine the level of psychological well-being and happiness among middle-aged women in Tabriz. Data were collected from December 2017 to February 2018 by face-to-face interviews, using structured questionnaires of happiness and psychological well-being.

Carboxymethylcellulose/MOF-5/Graphene oxide bio-nanocomposite as antibacterial drug nanocarrier agent.

In recent years, more attention was dedicated to developing new methods for designing of drug delivery systems. The aim of present work is to improve the efficiency of the antibacterial drug delivery process, and to realize and to control accurately the release. First, graphene oxide (GO) was prepared according to the modified Hummers method then the GO was modified with carboxymethylcellulose (CMC) and Zn-based metal-organic framework (MOF-5) through the solvothermal technique.