Cross-eye jamming method based on 1-bit digital coding metasurface.

Monopulse radar angle measurement technology is crucial for modern missile precision guidance systems due to its high accuracy and real-time capabilities. Cross-eye jamming (CEJ) is recognized as one of the most effective countermeasures against monopulse radar. However, traditional CEJ implementation requires complex amplitude and phase modulation through specialized hardware.

US-triggered on-demand NO-releasing biomimetic nanoparticle to Remodel endothelial microenvironment for enhancing atherosclerosis-specific gas therapy.

Atherosclerosis (AS) is a chronic inflammatory disease driven by endothelial dysfunction, vascular smooth muscle cell proliferation, and insufficient resolution of inflammation. Nitric oxide (NO) plays a crucial role in vascular homeostasis by promoting endothelial cell proliferation, maintaining endothelial integrity, suppressing smooth muscle cell hyperplasia, and exerting potent anti-inflammatory effects. However, clinical application of NO is hindered by its short half-life, lack of targeting, and uncontrolled release.

Phytochemical alkaloids orchestrate immunometabolism against viral infections.

The role of cholesterol metabolism in antiviral immunity has been established, but if and how this cholesterol-mediated immunometabolism can be regulated by specific small molecules is of particular interest in the quest for novel antiviral therapeutics. Here, we first demonstrate that NPC1 is the key cholesterol transporter for suppressing viral replication by changing cholesterol metabolism and triggering the innate immune response via systemic analyses of all possible cholesterol transporters. We then use the Connectivity Map (CMap), a systematic methodology for identifying functional connections between genetic perturbations and drug actions, to screen NPC1 inhibitors, and found that bis-benzylisoquinoline alkaloids (BBAs) exhibit high efficacy in the inhibition of viral infections.

Integrated Single-Cell and Transcriptome Analysis with Experimental Validation Reveals PANoptosis-Related Gene Signatures in the Immune Microenvironment of Autoimmune Thyroiditis.

Purpose: Autoimmune thyroiditis (AIT) is the most common organ-specific autoimmune disease, and its pathogenesis is closely related to the inflammatory microenvironment driven by immune cell penetration. The role of the newly proposed concept of PANoptosis in immune-related diseases is gradually being revealed. However, there is currently a lack of reports on PANoptosis in AIT.

Single-center retrospective analysis of 454 culture-positive patients with tinea capitis and measurement of pathogens regarding thermal tolerance at 37°C.

Background: This study aimed to analyze the epidemiological characteristics of tinea capitis (TC) and the changing trend of the pathogenic fungal spectrum in Hangzhou to assess the thermal tolerance of these pathogenic dermatophytes at 37°C.

Methods: Clinical, demographic, and mycological data of 454 TC patients were retrospectively collected.

Results: Among children with TC, 198 were females and 201 were males, with a median age of 5 years.