Publications by authors named "Yusuke Fujiyoshi"

Introduction: Patients with surgically altered gastrointestinal anatomy undergoing endoscopic retrograde cholangiopancreatography (ERCP) pose challenges due to anatomical distortions. Various patient and endoscopic factors, such as sex and positioning, may impact procedural success. It is unclear how these factors may impact the technical success of ERCP among patients with altered anatomy.

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Background And Study Aims: Endoscopic mucosal resection (EMR) remains an important treatment for high-grade dysplasia (HGD) and early esophageal adenocarcinoma (EAC) in Barrett's esophagus (BE). However, there are limited data regarding long-term recurrence rates. This study aimed to investigate the neoplasia recurrence rate following EMR with long-term follow-up.

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Background And Study Aims: Autoimmune atrophic gastritis (AIG) is a rare chronic autoimmune disease characterized by gastric mucosa inflammation and atrophy. Limited clinical data exist about AIG, especially in western populations. In addition, there are no western series on the magnifying endoscopic features in AIG.

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Gastroesophageal reflux disease (GERD) after peroral endoscopic myotomy (POEM) has been a limiting factor with POEM. Sling-fiber preservation during POEM was reported to reduce postoperative GERD in Japan. This study investigates the efficacy of this technique in a western population.

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Article Synopsis
  • The study focuses on developing guidelines for the safe use of fluoroscopy in gastrointestinal endoscopy, balancing its benefits with concerns about radiation exposure to patients and healthcare workers.
  • A modified Delphi method was used, involving three rounds of surveys with 46 experts, resulting in 43 proposed statements, of which 31 achieved consensus and were prioritized across various categories such as Patient Safety and Staff Safety.
  • The final consensus statements highlight the importance of education and safety measures, with a significant majority rated as high priority, aiming to enhance safety culture in healthcare settings while utilizing fluoroscopy.
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Background: Endoscopic mucosal resection (EMR) and endoscopic submucosal dissection (ESD) are effective treatments for Barrett's neoplasia. However, little is known about recurrence rates following these techniques. We compared long-term neoplasia recurrence rates following EMR and ESD.

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Background: Endoluminal Functional Lumen Imaging Probe (EndoFLIP) is a device that measures gastro-esophageal junction (GEJ) distensibility. However, it is not demonstrated that GEJ distensibility increases proportionally with varying gastric myotomy length in peroral endoscopic myotomy (POEM). This study aimed to investigate the association between gastric myotomy length in POEM and intraoperative EndoFLIP findings.

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Mucosal defect closure after colorectal endoscopic submucosal dissection (ESD) has the potential to reduce the occurrence of delayed adverse events (AEs) such as bleeding and perforation. This study aimed to assess the feasibility and effectiveness of the Loop9 method for closing mucosal defects following colorectal ESD. A retrospective single-center study was conducted using prospectively collected data from May 2020 to March 2023.

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Background And Aims: EMR and endoscopic submucosal dissection (ESD) are both accepted resection strategies for Barrett's esophagus-related neoplasia and esophageal adenocarcinoma (EAC). However, a lack of consensus exists regarding which technique offers superior outcomes. This study aims to systematically review the evidence comparing EMR versus ESD in treating Barrett's neoplasia and EAC.

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Background And Study Aim: Magnifying endoscopy enables the diagnosis of advanced neoplasia throughout the gastrointestinal tract. The unified magnifying endoscopic classification (UMEC) framework unifies optical diagnosis criteria in the esophagus, stomach, and colon, dividing lesions into three categories: non-neoplastic, intramucosal neoplasia, and deep submucosal invasive cancer. This study aims to ascertain the performance of North American endoscopists when using the UMEC.

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Article Synopsis
  • Resection of large nonpedunculated colorectal polyps can significantly lower the risk and death rate from colorectal cancer, highlighting the need for expert referral and planning of the procedure.
  • A Delphi study involving 24 international endoscopy experts identified 19 key factors—such as patient demographics, medications, and lesion details—that should be included in referrals for effective endoscopic resection.
  • The consensus gained from this study aims to enhance communication between referring physicians and therapeutic endoscopists, potentially improving the outcomes for patients with large colorectal polyps.
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Video 1Aberrant placement of functional lumen imaging probe into mediastinum during peroral endoscopic myotomy.

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Article Synopsis
  • The endoscopic pressure study integrated system (EPSIS) is a new tool that measures lower esophageal sphincter (LES) function by recording intragastric pressure during esophagogastroduodenoscopy (EGD), aimed at helping diagnose achalasia.
  • A case-control study involved 35 achalasia patients and 34 control patients, comparing EPSIS findings like pressure waveform patterns and maximum intragastric pressure (IGP-Max) between the two groups.
  • Results showed that all achalasia patients had an uphill pressure pattern, with IGP-Max providing high diagnostic accuracy (100% sensitivity, 58.8% specificity) at a cut-off of 15.8 mmHg, indicating EPS
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Background: Barrett's esophagus (BE) is a premalignant condition to esophageal adenocarcinoma (EAC). Low socioeconomic (SES) status adversely impacts care and outcomes in patients with EAC, but this has not been evaluated in BE. As the treatment of BE is similarly intensive, we aimed to evaluate the effect of SES on achieving complete eradication of intestinal metaplasia (CE-IM), dysplasia (CE-D) and development of invasive EAC.

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Article Synopsis
  • - The study assessed the effectiveness of the endoscopic pressure study integrated system (EPSIS) to evaluate anorectal function in older and younger patients, hypothesizing that it could help diagnose lower gastrointestinal disorders.
  • - A retrospective analysis of 30 patients showed significant differences in maximum rectal pressure measurements, with older patients (≥80 years) exhibiting lower pressure compared to younger patients (<80 years), indicating a decline in anorectal function with age.
  • - The findings suggest that EPSIS could be a useful tool for understanding age-related changes in anorectal physiology, recommending that future research explores its potential in routine screenings and diagnosing anorectal issues.
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  • Minimally invasive treatments for gastroesophageal reflux disease (GERD) are debated in terms of long-term effectiveness, with antireflux mucosectomy (ARMS) being a notable procedure that avoids foreign body insertion.
  • A study involving 88 patients with PPI-refractory GERD demonstrated that 68.3% experienced long-term benefits from ARMS, while 42% were able to stop using PPIs altogether.
  • The procedure was particularly effective for patients with reflux hypersensitivity, highlighting ARMS as a viable alternative that combines aspects of both surgical and medical treatments for GERD.
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  • The study examines the characteristics and diagnosis of achalasia using the Starlet high-resolution manometry (HRM) system compared to ManoScan and Sandhill systems, noting a higher frequency of type I achalasia in Starlet.
  • It analyzes various factors such as age, sex, Obesity, and disease duration that may affect integrated relaxation pressure (IRP) values, finding no significant impact from calcium channel blockers and nitrites on IRP despite symptom relief.
  • The research highlights that in recurrent achalasia cases, lower IRP values correlate with advanced disease progression, emphasizing the need for careful interpretation when making treatment decisions based on these measurements.
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  • The study aimed to determine how many cases of peroral endoscopic myotomy (POEM) are needed for proficiency among nonexperts compared to endoscopic submucosal dissection (ESD) experts.
  • Analysis of 1,121 POEM cases showed nonexperts needed 41-60 cases to reach proficiency, while experts needed only 21-40 cases, with operation times significantly decreasing as experience increased in both groups.
  • There were high clinical success rates for both groups (96.2-100%), but nonexperts experienced slightly higher adverse events and rates of gastroesophageal reflux disease (GERD), highlighting the need for tailored training programs.
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Article Synopsis
  • - Third-space endoscopy, or submucosal endoscopy, enables a variety of treatments within the submucosal and deeper layers of the gastrointestinal tract, showcasing significant advancements like peroral endoscopic myotomy (POEM) for achalasia.
  • - POEM not only effectively treats primary achalasia but also shows promising results for other esophageal motility disorders and serves as an option after previous unsuccessful treatments, although gastroesophageal reflux complications post-POEM have been a concern.
  • - The review discusses various emerging techniques related to submucosal tunneling, including tumor resection and specialized procedures for diverticula and gastroparesis, aiming to summarize recent advancements and guide future research in therapeutic end
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Article Synopsis
  • The endoscopic pressure study integrated system (EPSIS) is a new diagnostic tool for assessing gastroesophageal reflux disease (GERD) by measuring intragastric pressure during endoscopy.
  • A study investigated the link between EPSIS results and lower esophageal sphincter (LES) function, comparing EPSIS with high-resolution manometry (HRM).
  • The findings revealed that EPSIS parameters, such as pressure difference and pressure gradient, are significantly correlated with LES pressures, supporting its effectiveness as a diagnostic tool for GERD.
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  • The study aimed to analyze the causes and persistence of chest pain in patients with achalasia-related esophageal motility disorders after undergoing peroral endoscopic myotomy (POEM).
  • It included 2,294 patients with chest pain and 1,280 without, finding that about 69.5% experienced complete relief from chest pain post-POEM, while 30.5% did not, with various factors influencing outcomes.
  • Key factors affecting chest pain prevalence and severity included age, sex, disease duration, and previous treatment, while the type of myotomy (anterior vs. posterior) could impact pain persistence, suggesting tailored approaches could enhance treatment efficacy.
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