Rapid and Additive-Free Synthesis of β-Sulfido Sulfonyl Fluorides through -Methyl-2-pyrrolidinone (NMP)-Promoted Thia-Michael Addition.

β-Sulfido sulfonyl fluorides, incorporating a clickable sulfonyl fluoride and a thioether motif, are valuable intermediates in chemical biology, materials science, and drug discovery. Herein, we developed a rapid and additive-free synthesis of these compounds via -methyl-2-pyrrolidinone (NMP)-promoted thia-Michael addition of thiols to ethene sulfonyl fluoride (ESF). The reaction proceeds smoothly under neutral conditions without the need for a base or catalyst, achieving high efficiency within 20 min.

The Role of Lipid Metabolism Disorders in Rhinitis and Asthma.

The current core theory of rhinitis and asthma is referred to as the antigen-antibody theory. However, the academic perspective is insufficient to explain the issues that arise in the epidemiology, pathophysiology, and clinical treatment of these diseases. So, the academic field of lipid metabolism disorders emerged.

CALIBRATION METHOD AND ABSOLUTE MEASUREMENTS OF AIR KERMA OF DIAGNOSTIC X-RAY REFERENCE QUALITIES USING A FREE-AIR IONISATION CHAMBER.

Accurate dose measurement is very important for diagnosing X-ray equipment. These equipment should be traced directly or indirectly to primary standard with as little uncertainty as possible. A parallel-plate free-air chamber was designed to measure air kerma of diagnostic X-ray absolutely.

Cross-linked thermosensitive nanohydrogels for ocular drug delivery with a prolonged residence time and enhanced bioavailability.

Aim: A temperature-triggered, cross-linked nano hydrogel formulation (NPs-gel) was prepared to prolong the residence time of dexamethasone (DXM) in the eye and increase its bioavailability.

Research Design And Methods: The NPs-gel was prepared by combining a high pressure homogenization method with a cold solution method. Soy lecithin E200, lecithin oil, glycerol, kolliphor P188, kolliphor P407, and polycarbophil were the excipients used for the formation of NPs-gel containing DXM.

PLGA Nanoparticle Platform for Trans-Ocular Barrier to Enhance Drug Delivery: A Comparative Study Based on the Application of Oligosaccharides in the Outer Membrane of Carriers.

Purpose: The trans-ocular barrier is a key factor limiting the therapeutic efficacy of triamcinolone acetonide. We developed a poly(lactic-co-glycolic acid) nanoparticles (PLGA NPs) surface modified respectively with 2-hydroxypropyl-β-cyclodextrin (2-HP-β-CD), chitosan oligosaccharide and trehalose. Determination of the drug/nanoparticles interactions, characterization of the nanoparticles, in vivo ocular compatibility tests, comparisons of their corneal permeability and their pharmacokinetics in aqueous humor were carried out.

Characterisation of 2-HP-β-cyclodextrin-PLGA nanoparticle complexes for potential use as ocular drug delivery vehicles.

2-HP-β-cyclodextrin-PLGA nanoparticle complexes were prepared to enhance the aqueous humour delivery of Triamcinolone acetonide. Drug-loaded 2-HP-β-CD/PLGA nanoparticle complexes prepared by adapting a quasi-emulsion solvent evaporation technique. In vitro drug release, in vitro transcorneal permeation study, histopathological study and in vivo transcorneal penetration of PLGA nanoparticles and 2-HP-β-CD/PLGA nanoparticle complexes were evaluated.

Study on contact performance of ultrasonic-assisted grinding surface.

The contact performance of ultrasonic-assisted grinding surface is studied in this paper. An improved simplified model of rough surface profile is proposed to find the microscopic feature parameters, such as the curvature radius of the asperity, which are suitable for contact analysis and calculation. Then a more accurate rough surface contact analysis model is obtained by combining the classical ZMC contact model.

Patients' subjective visual experiences during vitreous surgery under local anesthesia.

Objective: To investigate patient's visual experience during vitreous surgery under local anesthesia.

Methods: A prospective and randomized study of 76 patients that underwent vitreous surgeries in our hospital between July 2010 and December 2010 was designed. All patients were interviewed half an hour before and within 1 hour after the surgery using a standardized questionnaire.