Impact of Pathological Grades of Metabolic Dysfunction-Associated Steatotic Liver Disease on Weight Loss Following Laparoscopic Sleeve Gastrectomy.

Purpose: The impact of hepatic steatosis severity on postoperative weight loss outcomes remains unclear. This study aimed to evaluate the effect of fatty liver severity on percentage of excess weight loss (%EWL) in patients undergoing laparoscopic sleeve gastrectomy (LSG).

Methods: This retrospective cohort study included 226 patients with obesity who underwent LSG.

Umbilical cord mesenchymal stem cell exosomal miR-143-3p delays endothelial cell senescence through targeting COX-2.

Senescence of vascular endothelial cells leads to endothelial dysfunction and exacerbates atherosclerosis. In this study, we presented evidence that exosomes derived from human umbilical cord mesenchymal stem cells (hucMSC-Exos) could delay endothelial cell senescence, promote endothelial cell proliferation, and enhance angiogenic activity in vitro. The miRNA profiling analysis revealed a high expression of miR-143-3p in hucMSC-Exos, which was further upregulated in endothelial cells treated with hucMSC-Exos.

FTO rs1121980 polymorphism contributes to coronary artery disease susceptibility in a Chinese Han population.

Background: The fat mass and obesity-associated protein (FTO) has been showed to be involved in the pathogenesis and progression of coronary artery disease (CAD). However, the effects of FTO variants on CAD risk remain poorly understood. We herein genotyped three SNPs (rs1121980, rs72803657, and rs4783818) in FTO to investigate the influence of FTO polymorphisms on individual susceptibility to CAD.

Novel subtype of obesity influencing the outcomes of sleeve gastrectomy: Familial aggregation of obesity.

Background: Differences in the preoperative characteristics and weight loss outcomes after sleeve gastrectomy (SG) between patients with familial aggregation of obesity (FAO) and patients with sporadic obesity (SO) have not been elucidated.

Aim: To explore the impact of SG on weight loss and the alleviation of obesity-related comorbidities in individuals with FAO.

Methods: A total of 193 patients with obesity who underwent SG were selected.